A putatively adaptive missense variant in ICAM1 is associated with systolic blood pressure in Andean highlanders
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DOI: 10.1152/physiol.2023.38.s1.5734515
Abstract: Hypobaric hypoxia exerts a significant evolutionary pressure on highlanders who have resided at high altitude for thousands of years. This evolutionary pressure has resulted in signatures of natural selection within native highlanders’ genomes, some of… read more here.
Keywords: putatively adaptive; andean highlanders; pressure; physiology ... See more keywords
Putatively adaptive missense variant at Adrenergic Receptor Alpha-1A associated with decreased risk of Chronic Mountain Sickness in Andean highlanders
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735177
Abstract: Andean highlanders living at high altitude (>4200 m) for hundreds of generations exhibit distinct cardiovascular and ventilatory traits in response to environmental stress. Adrenergic Receptor Alpha-1A ( ADRA1A), a gene coding for the Alpha 1-A… read more here.
Keywords: mountain sickness; putatively adaptive; andean highlanders; physiology ... See more keywords