Independent Validation of Effect of HSD3B1 Genotype on Response to Androgen-Deprivation Therapy in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.0147
Abstract: Independent Validation of Effect of HSD3B1 Genotype on Response to Androgen-Deprivation Therapy in Prostate Cancer Substantial advances have been made in the development of therapeutic biomarkers in various cancers, but not in prostate cancer. A… read more here.
Keywords: therapy; androgen; response; prostate cancer ... See more keywords
IL-1β Is an Androgen-Responsive Target in Macrophages for Immunotherapy of Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206889
Abstract: Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving the growth of prostate cancer (PCa) epithelial cells. However, the understanding of the role of androgen in… read more here.
Keywords: androgen responsive; prostate cancer; pca; androgen ... See more keywords
Social and demographic correlates of male androgen levels in wild white‐faced capuchin monkeys (Cebus capucinus)
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Primatology"
DOI: 10.1002/ajp.22653
Abstract: The Challenge Hypothesis, designed originally to explain the patterning of competitive behavior and androgen levels in seasonally breeding birds, predicts that males will increase their androgen levels in order to become more competitive in reproductive… read more here.
Keywords: faced capuchin; androgen; monkeys cebus; white faced ... See more keywords
Exercise is neuroprotective on the morphology of somatic motoneurons following the death of neighboring motoneurons via androgen action at the target muscle
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22794
Abstract: Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in… read more here.
Keywords: androgen; muscle; androgen action; exercise ... See more keywords
Study of novel androgen receptor V770 variant in androgen insensitivity syndrome patients reveals the transitional state of the androgen receptor ligand binding domain homodimer
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4599
Abstract: We report the discovery of the androgen receptor missense mutation V770D, that was found in two sisters suffering from complete androgen insensitivity. Experimental validation of AR V770 variants demonstrated that AR V770D was transcriptionally inactive… read more here.
Keywords: v770; lbd dimer; androgen receptor; dimerization ... See more keywords
Combined androgen blockade (CAB) versus luteinizing hormone-releasing hormone (LHRH) agonist monotherapy for androgen deprivation therapy
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Urology"
DOI: 10.1007/s00345-019-02847-y
Abstract: Purpose Combined androgen blockade (CAB) and luteinizing hormone-releasing hormone (LHRH) agonist monotherapy are commonly used in androgen deprivation therapy (ADT). In this randomized clinical trial, we aimed to compare the two methods of ADT in… read more here.
Keywords: hormone; lhrh agonist; agonist monotherapy; androgen ... See more keywords
Influence of androgen levels on conception probability in patients undergoing fertility treatment: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-019-05079-y
Abstract: PurposePrimary and secondary sterility have become an issue of increasing importance due to demographic and social changes in society. Data regarding the association between female androgen levels and the probability of successful conception after fertility… read more here.
Keywords: fertility treatment; study; androgen levels; androgen ... See more keywords
Comparative assessment of prognostic outcomes between first-generation antiandrogens and novel androgen-receptor-axis-targeted agents in patients with non-metastatic castration-resistant prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-019-01412-2
Abstract: BackgroundTo compare the prognostic outcomes between first-generation antiandrogen (FGA) and novel androgen-receptor-axis-targeted agent (ARATA) as first-line therapy in patients with non-metastatic castration-resistant prostate cancer (nmCRPC).MethodsThis study retrospectively included a total of 103 consecutive nmCRPC patients… read more here.
Keywords: prostate; prognostic outcomes; androgen; line ... See more keywords
Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-020-09511-x
Abstract: Androgen deprivation therapy (ADT) via surgical or chemical castration frequently fails to halt lethal castration-resistant prostate cancer (CRPC), which is induced by multiple mechanisms involving constitutive androgen receptor (AR) splice variants, AR mutation, and/or de… read more here.
Keywords: qw07; androgen; prostate cancer; compound ... See more keywords
Differential expression of AP-1 transcription factors in human prostate LNCaP and PC-3 cells: role of Fra-1 in transition to CRPC status
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3012-2
Abstract: Androgen receptor (AR) signaling axis plays a vital role in the development of prostate and critical in the progression of prostate cancer. Androgen withdrawal initially regresses tumors but eventually develops into aggressive castration-resistant prostate cancer… read more here.
Keywords: transition; androgen; lncap cells; lncap ... See more keywords
Kaempferol suppresses androgen-dependent and androgen-independent prostate cancer by regulating Ki67 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07307-2
Abstract: PURPOSE Kaempferol is a natural flavonoid that has been reported to be active against many cancers, including prostate cancer, breast cancer and colon cancer. In our previous study, we found kaempferol could act as a… read more here.
Keywords: cancer; expression; androgen; kaempferol ... See more keywords