The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00107a
Abstract: Etoposide (Eto) is a toxic drug that shows promise in treating prostate cancer (PCa) but confers significant side effects, and has poor solubility and bioavailability. Nanoparticles are quite successful in overcoming such problems. Multifunctional nanoparticles… read more here.
Keywords: spion; drug; androgen dependent; eto ... See more keywords
Evaluation of androgen-dependent skin findings of polycystic ovary syndrome (PCOS)
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2162496
Abstract: Abstract Aim The purpose of the study was to investigate the biochemical and metabolic abnormalities related to the cutaneous characteristics of PCOS. Material–Methods Patients diagnosed with PCOS were included in the study. Demographic data and… read more here.
Keywords: pcos; dependent skin; androgen dependent; skin findings ... See more keywords
Cabozantinib plus androgen deprivation therapy in patients with androgen-dependent metastatic prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.6_suppl.169
Abstract: 169Background: Cabozantinib (Cabo), a tyrosine kinase inhibitor of c-Met and VEGFR2, modulates the tumor microenvironment in a therapeutically favorable manner. We combined Cabo with androgen deprivation therapy (ADT) in patients (pts) with androgen-dependent metastatic prostate… read more here.
Keywords: androgen dependent; dependent metastatic; deprivation therapy; cancer ... See more keywords
Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.28059
Abstract: Glucuronidation controls androgen levels in the prostate and the dysregulation of enzymes in this pathway is associated with castration resistant prostate cancer. UDP-glucose dehydrogenase (UGDH) produces UDP-glucuronate, the essential precursor for glucuronidation, and its expression… read more here.
Keywords: cancer; altered glucuronidation; androgen dependent; prostate cancer ... See more keywords
Profiling of Androgen-Dependent Enhancer RNAs Expression in Human Prostate Tumors: Search for Malignancy Transition Markers
Sign Up to like & getrecommendations! Published in 2021 at "Research and Reports in Urology"
DOI: 10.2147/rru.s328661
Abstract: Introduction Although the ability of androgens to promote prostate cancer development has been known for decades, the molecular mechanisms of androgen receptor (AR) signaling in the tumorigenesis remain unclear. Enhancer RNAs (eRNAs) transcribed from strong… read more here.
Keywords: expression; androgen dependent; prostate; enhancer rnas ... See more keywords
Androgen-Dependent Prostate Cancer Cells Reprogram Their Metabolic Signature upon GLUT1 Upregulation by Manganese Superoxide Dismutase
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020313
Abstract: Prostate cancer is the second leading cause of cancer in men across the globe. The prostate gland accounts for some unique glycolytic metabolic characteristics, which causes the metabolic features of prostate tumor initiation and progression… read more here.
Keywords: cancer; prostate cancer; superoxide dismutase; androgen dependent ... See more keywords
An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15113033
Abstract: The aminosteroid derivative RM-581 blocks with high potency the growth of androgen-dependent (AR+) prostate cancer VCaP, 22Rv1, and LAPC-4 cells. Notably, RM-581 demonstrated superior antiproliferative activity in LAPC-4 cells compared to enzalutamide and abiraterone, two… read more here.
Keywords: androgen dependent; prostate cancer; aminosteroid derivative; dependent prostate ... See more keywords
Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and -Independent Pathways in Prostate Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076245
Abstract: The androgen-dependent or -independent pathways are regarded as primary therapeutic targets for the neoplasm of the prostate. Mucosa-associated lymphoid tissue 1 (MALT1) acting as a paracaspase in the regulation of nuclear factor κB (NF-κB) signal… read more here.
Keywords: dependent independent; independent pathways; androgen receptor; androgen ... See more keywords
Male-predominant galanin mediates androgen-dependent aggressive chases in medaka
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.59470
Abstract: Recent studies in mice demonstrate that a subset of neurons in the medial preoptic area (MPOA) that express galanin play crucial roles in regulating parental behavior in both sexes. However, little information is available on… read more here.
Keywords: androgen dependent; galanin; galanin neurons; mpoa galanin ... See more keywords