Association of androgen excess and bone mineral density in women with classical congenital adrenal hyperplasia with 21-hydroxylase deficiency
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Osteoporosis"
DOI: 10.1007/s11657-022-01090-0
Abstract: Summary The relationship between androgen excess and bone health in patients with congenital adrenal hyperplasia (CAH) with 21-hydroxylase (21-OH) deficiency is not fully understood. This study demonstrated positive correlations between androgen hormones and bone mineral… read more here.
Keywords: bmd; androgen excess; lumbar spine; deficiency ... See more keywords
Postmenopausal Hyperandrogenism: Evaluation and Treatment Strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2020.12.002
Abstract: Evidence of clinical and/or biochemical androgen excess poses a unique differential in postmenopausal women. Some signs and symptoms of postmenopausal hyperandrogenism can be normal and attributed to the natural aging process. However, the causes of… read more here.
Keywords: androgen excess; hyperandrogenism; hyperandrogenism evaluation; evaluation treatment ... See more keywords
The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
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DOI: 10.1038/s41598-017-08559-w
Abstract: Pregnant women with polycystic ovary syndrome (PCOS) are often overweight or obese. To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed… read more here.
Keywords: androgen excess; metabolism placental; obese dams; androgen ... See more keywords
Non-PCOS Hyperandrogenic Disorders in Adolescents.
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DOI: 10.1055/s-0041-1742259
Abstract: Hyperandrogenism-clinical features resulting from increased androgen production and/or action-is not uncommon in peripubertal girls. Hyperandrogenism affects 3 to 20% of adolescent girls and often is associated with hyperandrogenemia. In prepubertal girls, the most common etiologies… read more here.
Keywords: androgen excess; non pcos; androgen; hyperandrogenic disorders ... See more keywords
Lipid-induced mononuclear cell cytokine secretion in the development of metabolic aberration and androgen excess in polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction"
DOI: 10.1093/humrep/deaa056
Abstract: STUDY QUESTION What is the effect of saturated fat ingestion on mononuclear cell (MNC) TNFα, IL-6 and IL-1β secretion and circulating IL-6 levels in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Women with PCOS… read more here.
Keywords: androgen excess; secretion; androgen; metabolic aberration ... See more keywords
165 Randel Lecture: Androgen Excess Domestic Livestock Models—What can they Tell us About the Mechanisms Underlying Anovulation?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Animal Science"
DOI: 10.1093/jas/skad068.080
Abstract: Ovulatory disorders are a major factor in female infertility. Our laboratory has identified several populations of cows and a population of sheep that have excess androgen (High A4) in dominant follicles and ovarian cortex cultures… read more here.
Keywords: follicular arrest; androgen excess; ovarian cortex; cortex ... See more keywords
Approach to androgen excess in women: Clinical and biochemical insights
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DOI: 10.1111/cen.14710
Abstract: Androgen excess in women typically presents clinically with hirsutism, acne or androgenic alopecia. In the vast majority of cases, the underlying aetiology is polycystic ovary syndrome (PCOS), a common chronic condition that affects up to… read more here.
Keywords: excess women; approach androgen; pathology; androgen ... See more keywords
Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13110
Abstract: Polycystic ovary syndrome (PCOS) is associated with androgen excess and, frequently, hyperactive pulsatile luteinizing hormone (LH) secretion. Although the origins of PCOS are unclear, evidence from pre‐clinical models implicates androgen signalling in the brain in… read more here.
Keywords: gnrh neurons; androgen excess; female mice; dht ... See more keywords
Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.98607
Abstract: Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed to chronic androgen excess using dihydrotestosterone (DHT)… read more here.
Keywords: predisposes female; androgen excess; type diabetes; female mice ... See more keywords
Androgen excess in breast cancer development: implications for prevention and treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine-related cancer"
DOI: 10.1530/erc-18-0429
Abstract: The aim of this review is to highlight the pivotal role of androgen excess in the development of breast cancer. Available evidence suggests that testosterone controls breast epithelial growth through a balanced interaction between its… read more here.
Keywords: androgen excess; breast; androgen; breast cancer ... See more keywords
Androgen Excess Induced Mitochondrial Abnormality in Ovarian Granulosa Cells in a Rat Model of Polycystic Ovary Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.789008
Abstract: Background Androgen excess could profoundly lead to follicular dysplasia or atresia, and finally result in polycystic ovary syndrome (PCOS); however, the exact mechanism remains to be fully elucidated. Methods PCOS model rats were induced by… read more here.
Keywords: model rats; pcos model; polycystic ovary; ovary syndrome ... See more keywords