FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13030
Abstract: The growth of prostate cancer is dependent on the androgen receptor (AR), which serves as a ligand-specific transcription factor. Although two immunophilins, FKBP51 and FKBP52, are known to regulate AR activity, the precise mechanism remains… read more here.
Keywords: cancer; androgen receptor; fkbp51 fkbp52; prostate cancer ... See more keywords
The sex‐dependent role of the androgen receptor in glioblastoma: results of molecular analyses
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13262
Abstract: We sought to analyse the androgen receptor (AR) in glioblastoma (GBM) due to the location of the AR gene on chromosome X, often reported with shorter survival and higher prevalence of GBM among males. Copy… read more here.
Keywords: sex dependent; androgen receptor; expression; receptor glioblastoma ... See more keywords
Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300070
Abstract: PRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood. A Prdm16 luciferase knockin reporter mouse model is generated, enabling high… read more here.
Keywords: prdm16; androgen receptor; beige adipocyte; expression ... See more keywords
Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5587
Abstract: Prostate cancer (PCa) is a major cause of cancer morbidity and mortality for men globally, and androgen signaling clearly drives its onset and progression. Androgen receptor (AR) regulation is complex and remains elusive, despite several… read more here.
Keywords: par14 interacts; androgen receptor; prostate cancer; cancer ... See more keywords
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200548
Abstract: Androgen receptor targeted therapies for prostate cancer have serious limitations in advanced stages of the disease. While resistance to the FDA‐approved enzalutamide is extensively documented, novel therapies based on epichlorohydrin scaffolds (EPI) are currently in… read more here.
Keywords: epi 001; androgen receptor; prostate cancer; enzalutamide epi ... See more keywords
Equine metabolism of the selective androgen receptor modulator YK-11 in urine and plasma following oral administration.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3425
Abstract: YK-11 is a steroidal selective androgen receptor modulator, a compound class prohibited in both equine racing and human sports because of their potentially performance enhancing properties. YK-11 is easily accessible via internet-based supplement vendors making… read more here.
Keywords: metabolism; selective androgen; receptor modulator; androgen receptor ... See more keywords
In-depth metabolic study of non-steroidal selective androgen receptor modulator - GSK2881078 in thoroughbred horses and horse liver microsomes for doping control.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3469
Abstract: Non-steroidal selective androgen receptor modulators (SARMs) are a novel class of compounds that have not yet been clinically approved; however, they appear to have a better anabolic/androgenic ratio than steroids and cause slighter side effects.… read more here.
Keywords: steroidal selective; androgen receptor; non steroidal; selective androgen ... See more keywords
Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32120
Abstract: Androgen receptor (AR) has been reported to play an important role in the development and progression of man's prostate cancer. Hepatocellular carcinoma (HCC) is also male-dominant, but the role of AR in HCC remains poorly… read more here.
Keywords: liver steatosis; phosphorylation; androgen receptor; hcc ... See more keywords
Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32242
Abstract: Darolutamide is a novel androgen receptor (AR) antagonist with a distinct chemical structure compared to other AR antagonists and currently in clinical Phase 3 trials for prostate cancer. Using cell‐based transactivation assays, we demonstrate that… read more here.
Keywords: cancer; androgen receptor; darolutamide; prostate cancer ... See more keywords
Androgen Receptor in Neurons Slows Age‐Related Cortical Thinning in Male Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3625
Abstract: Androgens via the androgen receptor (AR) are required for optimal male bone health. The target cell(s) for the effects of androgens on cortical bone remain(s) incompletely understood. In females, estrogen receptor alpha in neurons is… read more here.
Keywords: arko mice; bone; androgen receptor; mice ... See more keywords
Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25751
Abstract: Stress urinary incontinence (SUI), a prevalent condition, is represented by an involuntary leakage of urine that results, at least in part, from weakened or damaged pelvic floor muscles and is triggered by physical stress. Current… read more here.
Keywords: biochemistry; pelvic floor; muscle; floor ... See more keywords