Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2020.11.009
Abstract: SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the disease and potential treatment options remains limited. The infection occurs through binding of the virus with angiotensin converting enzyme 2… read more here.
Keywords: androgen signaling; covid; signaling regulates; levels associated ... See more keywords
Regulation of meiotic progression by Sertoli-cell androgen signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-05-0334
Abstract: Androgen receptor (AR) signaling in Sertoli cells is known to be important for germ-cell progression through meiosis, but the extent to which androgens indirectly regulate specific meiotic stages is not known. Here, we combine synchronization… read more here.
Keywords: sertoli cell; cell androgen; cell; androgen signaling ... See more keywords
Abstract B011: Synergistic activity of tazemetostat in combination with androgen signaling inhibitors in preclinical models of prostate cancer demonstrates potential for clinical expansion
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-b011
Abstract: Prostate cancer (PCa) is the second leading cause of cancer death among men in the United States. Current available treatments include chemical castration and therapies targeting androgen receptor (AR) signaling pathways. Although initial responses are… read more here.
Keywords: combination; cancer; activity; androgen signaling ... See more keywords
Adiposity and response to androgen signaling inhibition (ASI) in men with metastatic castration-resistant prostate cancer (mCRPC).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.72
Abstract: 72Background: Improved understanding of how host factors influence the efficacy and toxicity of ASI could improve outcomes. Adiposity increases the risk for recurrence and lethal disease in men wit... read more here.
Keywords: response androgen; inhibition asi; androgen signaling; signaling inhibition ... See more keywords
One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.910964
Abstract: In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation. Since then, our knowledge of androgen impacts on differentiation of the male internal (Wolffian duct)… read more here.
Keywords: genitalia; actions androgen; conserved actions; external genitalia ... See more keywords
Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.66118
Abstract: Disruption of androgen signaling is known to cause testicular malformation and defective spermatogenesis in zebrafish. However, knockout of cyp17a1, a key enzyme responsible for the androgen synthesis, in ar-/- male zebrafish paradoxically causes testicular hypertrophy… read more here.
Keywords: spermatogenesis; cyp17a1; progestin; spermatogenesis zebrafish ... See more keywords