LKB1 suppresses androgen synthesis in a mouse model of hyperandrogenism via IGF‐1 signaling
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DOI: 10.1002/2211-5463.12723
Abstract: Polycystic ovary syndrome (PCOS) is a major cause of anovulatory sterility in women, and most PCOS patients exhibit hyperandrogenism (HA). Liver kinase b1 (LKB1) is a tumor suppressor that has recently been reported to be… read more here.
Keywords: via igf; igf signaling; androgen synthesis; hyperandrogenism ... See more keywords
Androgen synthesis inhibition increases behavioural flexibility and mPFC tyrosine hydroxylase in gonadectomized male rats
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DOI: 10.1111/jne.13128
Abstract: Behavioural flexibility is essential to adapt to a changing environment and depends on the medial prefrontal cortex (mPFC). Testosterone administration decreases behavioural flexibility. It is well known that testosterone is produced in the gonads, but… read more here.
Keywords: behavioural flexibility; tyrosine hydroxylase; mpfc; male rats ... See more keywords
AR Signaling in Prostate Cancer Regulates a Feed-Forward Mechanism of Androgen Synthesis by Way of HSD3B1 Upregulation
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DOI: 10.1210/en.2018-00283
Abstract: 3βHSD1 enzymatic activity is essential for synthesis of potent androgens from adrenal precursor steroids in prostate cancer. A germline variant in HSD3B1, the gene that encodes 3βHSD1, encodes for a stable enzyme, regulates adrenal androgen… read more here.
Keywords: androgen synthesis; prostate cancer; androgen; hsd3b1 ... See more keywords
Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank.
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DOI: 10.1530/eje-21-0996
Abstract: Context A sex discordance in COVID exists, with males disproportionately affected. Although sex steroids may play a role in this discordance, no definitive genetic data exist to support androgen-mediated immune suppression for viral susceptibility, nor… read more here.
Keywords: covid susceptibility; covid; susceptibility; androgen synthesis ... See more keywords
High Throughput scRNA-Seq Provides Insights Into Leydig Cell Senescence Induced by Experimental Autoimmune Orchitis: A Prominent Role of Interstitial Fibrosis and Complement Activation
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DOI: 10.3389/fimmu.2021.771373
Abstract: Leydig cells (Lc), located in the interstitial space of the testis between seminiferous tubules, produce 95% of testosterone in male individuals, which is pivotal for male sexual differentiation, spermatogenesis, and maintenance of the male secondary… read more here.
Keywords: experimental autoimmune; autoimmune orchitis; senescence; high throughput ... See more keywords