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   Articles with "andrographolide derivative" as a keyword



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Andrographolide derivative ameliorates dextran sulfate sodium‐induced experimental colitis in mice

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recommendations! Published in 2019 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2019.03.019

Abstract: Graphical abstract Figure. No caption available. &NA; The therapeutic efficacy of immunosuppressive agents has been intensively studied for colitis management. We synthesized a series of andrographolide derivatives and reported their structure‐activity‐relationship and anti‐inflammatory activity in… read more here.

Keywords: bgr catenin; dextran sulfate; sulfate sodium; colitis ... See more keywords
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AGS-30, an andrographolide derivative, suppresses tumor angiogenesis and growth in vitro and in vivo.

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recommendations! Published in 2019 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2019.113694

Abstract: Poor bioavailability and limited efficacy are challenges associated with using andrographolide as a therapeutic agent. We recently synthesized AGS-30, a new andrographolide derivative, in our laboratory. In this study we investigated the potential anti-tumor effect… read more here.

Keywords: growth; angiogenesis; derivative suppresses; andrographolide derivative ... See more keywords
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Andrographolide derivative AL-1 reduces intestinal permeability in dextran sulfate sodium (DSS)-induced mice colitis model.

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recommendations! Published in 2019 at "Life sciences"

DOI: 10.1016/j.lfs.2019.117164

Abstract: AIMS This study was to assess whether andrographolide derivative (AL-1) could restore mucosal homeostasis and regulate tight junctions through MLCK-dependent pathway in DSS-induced colitis mice. MAIN METHODS Colitis mice model was induced by daily administration… read more here.

Keywords: intestinal permeability; dss induced; colitis; model ... See more keywords
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Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19

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recommendations! Published in 2021 at "RSC Advances"

DOI: 10.1039/d0ra10529e

Abstract: The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e., 14-deoxy-11,12-didehydroandrographolide with targets related to COVID-19 and their probable role in regulating multiple pathways in COVID-19 infection. SMILES of both… read more here.

Keywords: covid; system biology; andrographolide derivative; combination system ... See more keywords
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Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.773282

Abstract: Background and objective: Andrographis paniculata (AP) is a traditionally used herbaceous plant, whose main active constituent is andrographolide. Andrographolide derivative medications and herbal preparations of AP are often used to treat respiratory tract infections. This… read more here.

Keywords: meta analysis; clinical studies; derivative medications; andrographolide derivative ... See more keywords