Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202100732
Abstract: Naturally occurring compounds represent a vast pool of pharmacologically active entities. One of such compounds is andrographolide, which is endowed with many beneficial properties, including the activity against severe acute respiratory syndrome coronavirus type 2… read more here.
Keywords: target keap1; andrographolide derivatives; activity; derivatives target ... See more keywords
Andrographolide and its derivatives: Current achievements and future perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113710
Abstract: Natural product andrographolide isolated from the plant Andrographis paniculata shows a plethora of biological activities, including anti-tumor, anti-bacterial, anti-inflammation, anti-virus, anti-fibrosis, anti-obesity, immunomodulatory and hypoglycemic activities. Based on extensive chemical structural modifications, a series of… read more here.
Keywords: future perspectives; drug; derivatives current; current achievements ... See more keywords
Tricyclic Aza-Andrographolide Derivatives from Late-Stage Hydroamination and Their Anti-human Coronavirus (Anti-HCoV) Activity
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DOI: 10.1021/acsomega.2c02979
Abstract: A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination… read more here.
Keywords: andrographolide derivatives; human coronavirus; tricyclic aza; late stage ... See more keywords
Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway
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DOI: 10.1038/s41598-017-04673-x
Abstract: Andrographolide derivatives or analogs exhibit potent anti-inflammatory effects in several disease models through NF-κB activity. In this study, we synthesized different andrographolide derivatives and investigated their effects on the toll-like receptor (TLR)-induced production of pro-inflammatory… read more here.
Keywords: inflammatory cytokines; innate immunity; andrographolide derivatives; pro inflammatory ... See more keywords
Synthesis and Characterization of Andrographolide Derivatives as Regulators of βAPP Processing in Human Cells.
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DOI: 10.3390/molecules26247660
Abstract: Alzheimer's disease (AD) is a devastating neurodegenerative disorder, one of the main characteristics of which is the abnormal accumulation of amyloid peptide (Aβ) in the brain. Whereas β-secretase supports Aβ formation along the amyloidogenic processing… read more here.
Keywords: characterization; synthesis characterization; andrographolide derivatives; derivatives regulators ... See more keywords
Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020115
Abstract: Hand-foot-and-mouth disease (HFMD) caused by human enterovirus A71 (EV-A71) infection has been associated with severe neurological complications. With the lack of an internationally approved antiviral, coupled with a surge in outbreaks globally, EV-A71 has emerged… read more here.
Keywords: novel andrographolide; enterovirus a71; discovery novel; andrographolide derivatives ... See more keywords