Andrographolide inhibits the activation of NLRP3 inflammasome in patients with COPD
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DOI: 10.1183/13993003.congress-2018.pa5246
Abstract: Background: The activation of NLRP3 inflammasome is involved in the aggravated inflammatory response of COPD exacerbations. However, there is a lack of treatment options targeting this specific pathway while andrographolide is shown to benefit certain… read more here.
Keywords: activation nlrp3; copd; andrographolide inhibits; activation ... See more keywords
Andrographolide inhibits arrhythmias and is cardioprotective in rabbits.
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DOI: 10.18632/oncotarget.18051
Abstract: Andrographolide has a protective effect on the cardiovascular system. To study its cardic-electrophysiological effects, action potentials and voltage-gated Na+ (INa), Ca2+ (ICaL), and K+ (IK1, IKr, Ito and IKur) currents were recorded using whole-cell patch… read more here.
Keywords: aconitine induced; myocytes andrographolide; andrographolide inhibits; induced arrhythmias ... See more keywords
Andrographolide Inhibits Angiogenesis by Inhibiting the Mir-21-5p/TIMP3 Signaling Pathway
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DOI: 10.7150/ijbs.19194
Abstract: Angiogenesis provides nutrients and oxygen to promote tumor growth and affords a channel that facilitates tumor cell entry into the circulation. Andrographolide (Andro) possess anti-tumor activity; however, its direct effect on angiogenesis still needs to… read more here.
Keywords: inhibiting mir; angiogenesis; andrographolide inhibits; angiogenesis inhibiting ... See more keywords