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   Articles with "androstane receptor" as a keyword



Potent and Selective Human Constitutive Androstane Receptor Activator DL5055 Facilitates Cyclophosphamide-Based Chemotherapies.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c02064

Abstract: Enhancement of the metabolic conversion of cyclophosphamide (CPA) increases its therapeutic effects. Activation of the human constitutive androstane receptor (hCAR) induces CYP2B6, a key enzyme responsible for CPA bioactivation. Based on our previous hCAR activator… read more here.

Keywords: constitutive androstane; androstane receptor; human constitutive; hcar ... See more keywords

Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2

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recommendations! Published in 2019 at "Toxicological Sciences"

DOI: 10.1093/toxsci/kfy231

Abstract: Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and peroxisome proliferator-activated receptor alpha (PPARα) in rodent test systems often leads to increases in oxidative stress… read more here.

Keywords: activation oxidant; androstane receptor; constitutive androstane; activation ... See more keywords

Constitutive androstane receptor regulates the intestinal mucosal response to injury

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recommendations! Published in 2017 at "British Journal of Pharmacology"

DOI: 10.1111/bph.13787

Abstract: The pathogenesis of the inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), involves aberrant interactions between a genetically susceptible individual, their microbiota and environmental factors. Alterations in xenobiotic receptor expression and… read more here.

Keywords: receptor; androstane receptor; intestinal mucosal; constitutive androstane ... See more keywords

Constitutive androstane receptor (CAR) mediates pyrene‐induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells

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recommendations! Published in 2022 at "British Journal of Pharmacology"

DOI: 10.1111/bph.15934

Abstract: The constitutive androstane receptor (CAR), a known xenobiotic sensor, plays an important role in drug metabolism by regulating numerous genes. The polycyclic aromatic hydrocarbon pyrene, an environmental pollutant, is a CAR activator and induces mouse… read more here.

Keywords: car; receptor car; constitutive androstane; androstane receptor ... See more keywords

Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation

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recommendations! Published in 2018 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.118.083014

Abstract: Nuclear receptors mediate the hepatic induction of drug-metabolizing enzymes by xenobiotics. Not much is known about enzyme induction in liver tumors. Here, we treated tumor-bearing mice with phenobarbital, an activator of the constitutive androstane receptor… read more here.

Keywords: androstane receptor; constitutive androstane; ras raf; activation ... See more keywords

Clinical Relevance of the Constitutive Androstane Receptor

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recommendations! Published in 2022 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.121.000483

Abstract: Constitutive androstane receptor (CAR) (NR1I3), a xenobiotic receptor, has long been considered a master mediator of drug disposition and detoxification. Accumulating evidence indicates that CAR also participates in various physiologic and pathophysiological pathways regulating the… read more here.

Keywords: clinical relevance; car; constitutive androstane; androstane receptor ... See more keywords

Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver

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recommendations! Published in 2022 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvac145

Abstract: Abstract Imidacloprid (IMI) is the most frequently detected neonicotinoid pesticide in the environment. Despite typically low toxicity in vertebrates, IMI exposure is associated with liver and gastrointestinal toxicity. The mechanism underlying IMI toxicity in mammals… read more here.

Keywords: car; intestinal alterations; constitutive androstane; androstane receptor ... See more keywords