Paradoxical anesthesia: Sleep-like EEG during anesthesia induced by mesopontine microinjection of GABAergic agents
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113760
Abstract: General anesthetic agents are thought to induce loss-of-consciousness (LOC) and enable pain-free surgery by acting on the endogenous brain circuitry responsible for sleep-wake cycling. In clinical use, the entire CNS is exposed to anesthetic molecules… read more here.
Keywords: anesthesia induced; anesthesia; wake; microinjection ... See more keywords
Neurotoxicity of anesthetic drugs: an update
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000000482
Abstract: Purpose of review This article reviews the most recently published evidence that investigated anesthesia-induced neurotoxicity in both animals and humans, especially as it pertains to the perinatal period. Recent findings Several recent studies have focused… read more here.
Keywords: anesthesia induced; induced neurotoxicity; anesthetic drugs; neurotoxicity ... See more keywords
Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents
Sign Up to like & getrecommendations! Published in 2017 at "Anesthesiology"
DOI: 10.1097/aln.0000000000001812
Abstract: Background: Intraoperative hypothermia and postoperative pain control are two important clinical challenges in anesthesiology. Transient receptor potential vanilloid 1 has been implicated both in thermoregulation and pain. Transient receptor potential vanilloid 1 antagonists were not… read more here.
Keywords: receptor potential; anesthesia induced; transient receptor; potential vanilloid ... See more keywords
Inhalation anesthesia induced by isoflurane alters penicillin disposition in swine tissues
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Veterinary Pharmacology and Therapeutics"
DOI: 10.1111/jvp.12361
Abstract: Twelve healthy swine were dosed with penicillin G intramuscularly. Fluids and tissues samples were collected at the end of two periods of general anesthesia, performed 24 h apart. Tissue samples were collected by minimally invasive laparoscopy… read more here.
Keywords: inhalation anesthesia; anesthesia induced; tissue; swine ... See more keywords
Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/9281519
Abstract: Dry eye syndrome (DES) is an age-related condition increasingly detected in younger people of risk groups, including patients who underwent ocular surgery or long-term general anesthesia. Being a multifactorial disease, it is characterized by oxidative… read more here.
Keywords: mitochondria targeted; anesthesia induced; eye syndrome; skq1 ... See more keywords
Relevance of experimental paradigms of anesthesia induced neurotoxicity in the mouse
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0213543
Abstract: Routine general anesthesia is considered to be safe in healthy individuals. However, pre-clinical studies in mice, rats, and monkeys have repeatedly demonstrated that exposure to anesthetic agents during early post-natal periods can lead to acute… read more here.
Keywords: anesthesia induced; induced neurotoxicity; anesthesia; relevance experimental ... See more keywords
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Current Alzheimer research"
DOI: 10.2174/1567205015666181031145045
Abstract: BACKGROUND Preclinical and clinical evidence suggests that elderly individuals are at increased risk of cognitive decline after general anesthesia. General anesthesia is also believed to be a risk factor for Postoperative Cognitive Dysfunction (POCD) and… read more here.
Keywords: insulin; anesthesia induced; insulin treatment; intranasal insulin ... See more keywords
Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031128
Abstract: Since its invention, general anesthesia has been an indispensable component of modern surgery. While traditionally considered safe and beneficial in many pathological settings, hundreds of preclinical studies in various animal species have raised concerns about… read more here.
Keywords: anesthesia induced; protective strategies; developmental neurotoxicity; neurotoxicity ... See more keywords
Hemodynamic effects of norepinephrine versus phenylephrine infusion for prophylaxis against spinal anesthesia-induced hypotension in the elderly population undergoing hip fracture surgery: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "Korean Journal of Anesthesiology"
DOI: 10.4097/kja.20519
Abstract: Background Elderly population are at increased risk of spinal anesthesia-induced hypotension increasing their risk for postoperative morbidity and mortality. This study aimed to compare the hemodynamic effects of prophylactic infusion of norepinephrine (NE) versus phenylephrine… read more here.
Keywords: anesthesia induced; anesthesia; group; spinal anesthesia ... See more keywords