Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice
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DOI: 10.1002/brb3.957
Abstract: Postoperative cognitive dysfunction (POCD) is consistently associated with increased morbidity and mortality, which has become a major concern of patients and caregivers. Although POCD occurs mainly in aged patients, it happens at any age. Previous… read more here.
Keywords: anesthesia surgery; working memory; memory; adult mice ... See more keywords
Early Childhood General Anesthesia and Neurodevelopmental Outcomes in the Avon Longitudinal Study of Parents and Children Birth Cohort
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DOI: 10.1097/aln.0000000000003522
Abstract: Background: Most common anesthetic agents have been implicated in causing neurodegeneration in the developing animal brain, leading to warnings regarding their use in children. The hypothesis of this study was that exposure to general anesthesia… read more here.
Keywords: general anesthesia; anesthesia; anesthesia surgery; exposed children ... See more keywords
On the Challenges of Anesthesia and Surgery during Interplanetary Spaceflight
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DOI: 10.1097/aln.0000000000003789
Abstract: This focused review summarizes the medical, logistical, and environmental challenges that would be associated with dealing with a traumatic surgical case during an interplanetary space mission in the near future. read more here.
Keywords: anesthesia surgery; challenges anesthesia; surgery interplanetary; interplanetary spaceflight ... See more keywords
Neuroprotective effects of different doses of Maresin1 pretreatment in aged rats after anesthesia/surgery
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DOI: 10.1097/wnr.0000000000001900
Abstract: Objective The study is to investigate the neuroprotective effect of different doses of Maresin1 pretreatment in aged rats after anesthesia/surgery and the related mechanisms. Methods Aged male rats were randomly divided into a control group,… read more here.
Keywords: maresin1 pretreatment; anesthesia surgery; group; rats anesthesia ... See more keywords
The Effect of SIRT3/Ac-SOD2 Mediated Oxidative Stress and HCN1 Channel Activity on Anesthesia/Surgery Induced Anxiety-Like Behavior in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.783931
Abstract: Anxiety disorders are the most common psychiatric diseases, and perioperative factors often increase the incidence of anxiety. However, the mechanism and treatment for perioperative anxiety, especially anesthesia/surgery-induced postoperative anxiety, are largely unknown. Sirtuin 3 (SIRT3)… read more here.
Keywords: surgery induced; anxiety; anesthesia surgery; oxidative stress ... See more keywords
Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.628541
Abstract: Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients and has become a major concern for patients and caregivers. Previous studies demonstrated that synaptic plasticity is closely related to cognitive function, anesthesia and surgery… read more here.
Keywords: synaptic plasticity; anesthesia surgery; mtor; memory ... See more keywords
WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.688587
Abstract: Anesthesia/surgery has been reported to be associated with perioperative neurocognitive disorder (PND) in patients and induces cognitive impairment in mice. Previous studies demonstrate cyclosporine A (CsA) attenuates the anesthesia/surgery-induced cognitive impairment in mice. However, CsA… read more here.
Keywords: surgery; impairment mice; cognitive impairment; ws635 ... See more keywords
Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.748637
Abstract: Emerging evidence suggests that anesthesia and surgery may induce gut dysbiosis. Gut dysbiosis leads to imbalance in circulating contents of microbiota-derived metabolites and disrupts the integrity of the blood-brain barrier (BBB), contributing to postoperative cognitive… read more here.
Keywords: blood brain; gut; brain barrier; anesthesia surgery ... See more keywords
Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1021129
Abstract: Postoperative delirium (POD) is common in the elderly and is associated with poor clinical outcomes. Reactive oxygen species (ROS) and blood-brain barrier (BBB) damage have been implicated in the development of POD, but the association… read more here.
Keywords: anesthesia surgery; delirium like; anesthesia; cypa mmp9 ... See more keywords
Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.996223
Abstract: We investigated the protective effect of young plasma on anesthesia- and surgery-induced cognitive impairment and the potential underlying mechanism using bioinformatics, functional enrichment analysis, gene set enrichment analysis, Golgi-Cox staining, dendritic spine analysis, immunofluorescence assay,… read more here.
Keywords: induced cognitive; young plasma; cognitive impairment; surgery induced ... See more keywords
Risk factors and outcomes of intraoperative hypothermia in neonatal and infant patients undergoing general anesthesia and surgery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2023.1113627
Abstract: Objective The incidence of intraoperative hypothermia remains high in pediatric patients during anesthesia and surgery even though core body temperature monitoring and warming systems have been greatly improved in recent years. We analyzed the risk… read more here.
Keywords: general anesthesia; risk factors; hypothermia; anesthesia surgery ... See more keywords