Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment
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DOI: 10.1002/advs.202414397
Abstract: Postoperative cognitive dysfunction (POCD) frequently occurs after surgery, resulting in extended hospitalizations, higher healthcare expenses, and potential long‐term cognitive impairment. Despite its significant impact, effective preventive and therapeutic strategies for POCD are still lacking. Neuroinflammation… read more here.
Keywords: surgery; cognitive impairment; anesthesia surgery; hydrogen gene ... See more keywords
Inhibiting Liver-Derived C3 Protein Rescues Anesthesia/Surgery-Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis.
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DOI: 10.1002/advs.202502034
Abstract: Identifying peripheral proteins having therapeutic effects on cognitive impairment could provide beneficial insights into the prevention and treatment of cognition‐related disorders, including postoperative cognitive dysfunction (POCD) that is a common postoperative cognitive impairment mainly caused… read more here.
Keywords: cognitive impairment; induced cognitive; anesthesia surgery; surgery induced ... See more keywords
Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice
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DOI: 10.1002/brb3.957
Abstract: Postoperative cognitive dysfunction (POCD) is consistently associated with increased morbidity and mortality, which has become a major concern of patients and caregivers. Although POCD occurs mainly in aged patients, it happens at any age. Previous… read more here.
Keywords: anesthesia surgery; working memory; memory; adult mice ... See more keywords
Early Childhood General Anesthesia and Neurodevelopmental Outcomes in the Avon Longitudinal Study of Parents and Children Birth Cohort
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DOI: 10.1097/aln.0000000000003522
Abstract: Background: Most common anesthetic agents have been implicated in causing neurodegeneration in the developing animal brain, leading to warnings regarding their use in children. The hypothesis of this study was that exposure to general anesthesia… read more here.
Keywords: general anesthesia; anesthesia; anesthesia surgery; exposed children ... See more keywords
On the Challenges of Anesthesia and Surgery during Interplanetary Spaceflight
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DOI: 10.1097/aln.0000000000003789
Abstract: This focused review summarizes the medical, logistical, and environmental challenges that would be associated with dealing with a traumatic surgical case during an interplanetary space mission in the near future. read more here.
Keywords: anesthesia surgery; challenges anesthesia; surgery interplanetary; interplanetary spaceflight ... See more keywords
Neuroprotective effects of different doses of Maresin1 pretreatment in aged rats after anesthesia/surgery
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DOI: 10.1097/wnr.0000000000001900
Abstract: Objective The study is to investigate the neuroprotective effect of different doses of Maresin1 pretreatment in aged rats after anesthesia/surgery and the related mechanisms. Methods Aged male rats were randomly divided into a control group,… read more here.
Keywords: maresin1 pretreatment; anesthesia surgery; group; rats anesthesia ... See more keywords
Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation
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DOI: 10.1186/s12951-025-03502-y
Abstract: Perioperative neurocognitive disorder (PND), a prevalent neurological complication in elderly patients following anesthesia and surgery, has recently been linked to ferroptosis as a central pathogenic mechanism. Sirtuin-3 (SIRT3), a NAD+-dependent deacetylase, exhibits neuroprotective properties in… read more here.
Keywords: anesthesia surgery; mitochondrial gpx4; ferroptosis; neuronal ferroptosis ... See more keywords
The Effect of SIRT3/Ac-SOD2 Mediated Oxidative Stress and HCN1 Channel Activity on Anesthesia/Surgery Induced Anxiety-Like Behavior in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.783931
Abstract: Anxiety disorders are the most common psychiatric diseases, and perioperative factors often increase the incidence of anxiety. However, the mechanism and treatment for perioperative anxiety, especially anesthesia/surgery-induced postoperative anxiety, are largely unknown. Sirtuin 3 (SIRT3)… read more here.
Keywords: surgery induced; anxiety; anesthesia surgery; oxidative stress ... See more keywords
Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice
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DOI: 10.3389/fnagi.2021.628541
Abstract: Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients and has become a major concern for patients and caregivers. Previous studies demonstrated that synaptic plasticity is closely related to cognitive function, anesthesia and surgery… read more here.
Keywords: synaptic plasticity; anesthesia surgery; mtor; memory ... See more keywords
WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.688587
Abstract: Anesthesia/surgery has been reported to be associated with perioperative neurocognitive disorder (PND) in patients and induces cognitive impairment in mice. Previous studies demonstrate cyclosporine A (CsA) attenuates the anesthesia/surgery-induced cognitive impairment in mice. However, CsA… read more here.
Keywords: surgery; impairment mice; cognitive impairment; ws635 ... See more keywords
Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.748637
Abstract: Emerging evidence suggests that anesthesia and surgery may induce gut dysbiosis. Gut dysbiosis leads to imbalance in circulating contents of microbiota-derived metabolites and disrupts the integrity of the blood-brain barrier (BBB), contributing to postoperative cognitive… read more here.
Keywords: blood brain; gut; brain barrier; anesthesia surgery ... See more keywords