Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development
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DOI: 10.1038/s41421-024-00719-3
Abstract: Pre-implantation genetic testing for aneuploidy (PGT-A) is used in approximately half of in vitro fertilization cycles. Given the limited understanding of the genetics of human embryos, the current use of PGT-A is based on biologically… read more here.
Keywords: aneuploid cells; embryos harbor; mosaicism; human embryos ... See more keywords
A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution
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DOI: 10.1038/s41598-020-68729-1
Abstract: Aneuploidy is a feature of many cancers. Recent studies demonstrate that in the hematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells have reduced fitness and are efficiently purged from the bone marrow. However, early… read more here.
Keywords: aneuploid cells; selection; hematopoietic reconstitution; bone marrow ... See more keywords
Abstract IA015: Identifying and targeting synthetic lethalities of aneuploid (cancer) cells
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DOI: 10.1158/1538-8514.synthleth24-ia015
Abstract: Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a genetic hallmark of cancer cells, yet aneuploidy remains a biological enigma and a missed opportunity for cancer therapy. Aneuploid cells must cope with several… read more here.
Keywords: cancer; aneuploid cells; cancer cells; synthetic lethalities ... See more keywords
Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment
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DOI: 10.3390/cancers13236027
Abstract: Simple Summary In tissue homeostasis, aneuploid cells have been suggested to be recognized and eliminated by immune cells. However, these initiating cancer cells can evade the immune system and ultimately derivate a tumor. To better… read more here.
Keywords: tumor; cancer; aneuploid cells; lung cancer ... See more keywords
Telomere Shortening in Hematological Malignancies with Tetraploidization—A Mechanism for Chromosomal Instability?
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DOI: 10.3390/cancers9120165
Abstract: Aneuploidy, the presence of an abnormal number of chromosomes in a cell, is one of the most obvious differences between normal and cancer cells. There is, however, debate on how aneuploid cells arise and whether… read more here.
Keywords: aneuploid cells; mechanism; chromosomal instability; tetraploidization ... See more keywords
Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.61172
Abstract: Aneuploidy causes birth defects and miscarriages, occurs in nearly all cancers and is a hallmark of aging. Individual aneuploid cells can be eliminated from developing tissues by unknown mechanisms. Cells with ribosomal protein (Rp) gene… read more here.
Keywords: gene dose; competition; aneuploid cells; cell competition ... See more keywords