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Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68729-1
Abstract: Aneuploidy is a feature of many cancers. Recent studies demonstrate that in the hematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells have reduced fitness and are efficiently purged from the bone marrow. However, early…
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Keywords:
aneuploid cells;
selection;
hematopoietic reconstitution;
bone marrow ... See more keywords
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Published in 2021 at "Cancers"
DOI: 10.3390/cancers13236027
Abstract: Simple Summary In tissue homeostasis, aneuploid cells have been suggested to be recognized and eliminated by immune cells. However, these initiating cancer cells can evade the immune system and ultimately derivate a tumor. To better…
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Keywords:
tumor;
cancer;
aneuploid cells;
lung cancer ... See more keywords
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Published in 2017 at "Cancers"
DOI: 10.3390/cancers9120165
Abstract: Aneuploidy, the presence of an abnormal number of chromosomes in a cell, is one of the most obvious differences between normal and cancer cells. There is, however, debate on how aneuploid cells arise and whether…
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Keywords:
aneuploid cells;
mechanism;
chromosomal instability;
tetraploidization ... See more keywords
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Published in 2021 at "eLife"
DOI: 10.7554/elife.61172
Abstract: Aneuploidy causes birth defects and miscarriages, occurs in nearly all cancers and is a hallmark of aging. Individual aneuploid cells can be eliminated from developing tissues by unknown mechanisms. Cells with ribosomal protein (Rp) gene…
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Keywords:
gene dose;
competition;
aneuploid cells;
cell competition ... See more keywords