P-240 Human extracellular vesicles (EVs) secreted by aneuploid embryos potentiate development of non-invasive PGT-A RNA biomarkers and stimulate MUC1 up-regulation in primary endometrial stromal cells (ESCs)
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DOI: 10.1093/humrep/deab127.067
Abstract: Could EVs secreted by aneuploid embryos a) serve for development of RNA biomarkers for PGT-A and b) elicit a relevant transcriptomic response in decidualised ESCs? Aneuploid embryo EVs a) contain PPM1J, LINC00561, ANKRD34C and TMED10… read more here.
Keywords: embryos; aneuploid embryos; rna; evs secreted ... See more keywords
P–530 The use of wide thresholds for detecting intermediate chromosomal CNV up to 80% doesn’t improve PGT-A ability to discriminate true mosaic from uniformly aneuploid embryos
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DOI: 10.1093/humrep/deab130.529
Abstract: What is the effect of varying diagnostic thresholds on the accuracy of Next Generation Sequencing (NGS)-based preimplantation genetic testing for aneuploidies (PGT-A)? When single trophectoderm biopsies are tested, the employment of 80% upper threshold increases… read more here.
Keywords: uniformly aneuploid; aneuploid embryos; cnv; pgt ... See more keywords