The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α
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DOI: 10.1016/j.celrep.2018.09.060
Abstract: Summary Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploidy is poorly tolerated by normal somatic cells and acts as a barrier to transformation. Paradoxically,… read more here.
Keywords: inhibiting hif; kinase; p38 stress; aneuploidy tolerance ... See more keywords