Ciprofloxacin Accelerates Angiotensin-II-Induced Vascular Smooth Muscle Cells Senescence Through Modulating AMPK/ROS pathway in Aortic Aneurysm and Dissection
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-024-09892-z
Abstract: Aortic aneurysm and dissection (AAD) is a cardiovascular disease that poses a severe threat to life and has high morbidity and mortality rates. Clinical and animal-based studies have irrefutably shown that fluoroquinolones, a commonly prescribed… read more here.
Keywords: senescence; vascular smooth; aneurysm dissection; ciprofloxacin ... See more keywords
Aortic aneurysm and dissection in pregnancy: A case report
Sign Up to like & getrecommendations! Published in 2020 at "Case Reports in Women's Health"
DOI: 10.1016/j.crwh.2020.e00261
Abstract: We describe a 24-year-old pregnant woman at 34 weeks of gestation who presented to a community hospital with sharp chest pain radiating to her back. She was found to have a 6 cm ascending aortic… read more here.
Keywords: pregnancy; aneurysm dissection; aortic aneurysm; case ... See more keywords
Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.09.010
Abstract: Rupture of aortic aneurysm and dissection (AAD) remains a leading cause of death. Progressive smooth muscle cell (SMC) loss is a crucial feature of AAD that contributes to aortic dysfunction and degeneration, leading to aortic… read more here.
Keywords: death; aneurysm dissection; aortic aneurysm; programmed cell ... See more keywords
Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50036-2
Abstract: The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 participants were recruited for the screening of differentially expressed plasma microRNAs (miRNAs). We found that miR-1204 is significantly… read more here.
Keywords: aneurysm dissection; mir 1204; aortic aneurysm; mylk ... See more keywords
Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08403-2
Abstract: Aortic aneurysm and dissection (AAD) are severe cardiovascular conditions that carry significant risks and currently lack an effective treatment. Ursodeoxycholic acid (UDCA) can delay the onset of various metabolic diseases such as type 2 diabetes… read more here.
Keywords: ursodeoxycholic acid; aneurysm dissection; intestinal farnesoid; aortic aneurysm ... See more keywords
Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model
Sign Up to like & getrecommendations! Published in 2024 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2024.2322055
Abstract: ABSTRACT Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with complex mechanisms and a notably high mortality rate. Zebrafish (Danio rerio) serve as valuable models for AAD due to the conservation of their three-layered arterial… read more here.
Keywords: aminopropionic nitrile; adult zebrafish; aortic aneurysm; aneurysm dissection ... See more keywords
Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection.
Sign Up to like & getrecommendations! Published in 2023 at "European heart journal"
DOI: 10.1093/eurheartj/ehac823
Abstract: AIMS Whether changes in endothelial tight junctions (TJs) lead to the formation of thoracic aortic aneurysm and dissection (TAAD) and serve as an early indicator and therapeutic target remains elusive. METHODS AND RESULTS Single-cell RNA… read more here.
Keywords: aneurysm dissection; tight junctions; thoracic aortic; thoracic aortas ... See more keywords
Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of vascular research"
DOI: 10.1159/000509545
Abstract: Aortic aneurysms and dissections are silent and lethal conditions, whose pathogenesis remains incompletely understood. Although angiotensin II (AngII)-infused ApoE−/− mice have been widely used to study aortic aneurysm and dissection, early morphofunctional alterations preceding the… read more here.
Keywords: morphofunctional changes; aneurysm dissection; aortic aneurysm; dissection ... See more keywords
Further Evidence Supporting a Protective Role of Transforming Growth Factor-β (TGFβ) in Aortic Aneurysm and Dissection.
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.117.310031
Abstract: Aortic disease arises from abnormalities in size or structure of the vessel wall. An (fusiform) aneurysm is a localized dilatation of the aorta, usually defined as >150% of the normal diameter for a given segment.… read more here.
Keywords: transforming growth; aneurysm dissection; disease; growth factor ... See more keywords
Abstract 4363591: Geographic and Demographic Trends in Aortic Aneurysm and Dissection Mortality Among U.S. Adults Aged 65–75, 1999–2020
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4363591
Abstract: Background: Aortic aneurysm and dissection (AAD) are highly fatal in older adults. While AAD mortality has declined since 1999, reductions have been uneven across U.S. regions, sexes, and racial/ethnic groups, likely due to healthcare variability.… read more here.
Keywords: among adults; aneurysm dissection; mortality; aortic aneurysm ... See more keywords
March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/circresaha.124.325049
Abstract: BACKGROUND: Aortic aneurysm/dissection (AAD) is a life-threatening disease lacking effective pharmacological treatment. Protein ubiquitination plays a pivotal role in cardiovascular diseases. However, the possible contribution of the E3 ubiquitin ligase March2 (membrane-associated RING [really interesting… read more here.
Keywords: aneurysm dissection; pathology; aortic aneurysm; smooth muscle ... See more keywords