Imatinib prevents elastase-induced abdominal aortic aneurysm progression by regulating macrophage-derived MMP9.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172559
Abstract: Abdominal aortic aneurysm (AAA) is characterized with progressive weakening and considerable dilation of the aortic wall. Despite the high risk of mortality in the elderly population, there are still no clinical pharmacological therapies to alleviate… read more here.
Keywords: aortic aneurysm; macrophage; abdominal aortic; progression ... See more keywords
Cycloastragenol Inhibits Experimental Abdominal Aortic Aneurysm Progression
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DOI: 10.3390/biomedicines10020359
Abstract: The pathogenesis of abdominal aortic aneurysm involves vascular inflammation and elastin degradation. Astragalus radix contains cycloastragenol, which is known to be anti-inflammatory and to protect against elastin degradation. We hypothesized that cycloastragenol supplementation inhibits abdominal… read more here.
Keywords: abdominal aortic; cycloastragenol; aneurysm; aortic aneurysm ... See more keywords
Nicotine Administration Augments Abdominal Aortic Aneurysm Progression in Rats
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DOI: 10.3390/biomedicines11051417
Abstract: Inflammation and elastin degradation are key hallmarks in the pathogenesis of abdominal aortic aneurysms (AAAs). It has been acknowledged that activation of alpha7 nicotinic acetylcholine receptors (α7nAChRs) attenuates inflammation, termed the cholinergic anti-inflammatory pathway (CAP).… read more here.
Keywords: nicotine administration; progression; abdominal aortic; aneurysm progression ... See more keywords