Irigenin alleviates angiotensin II-induced oxidative stress and apoptosis in HUVEC cells by activating Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21802
Abstract: Endothelial dysfunction is closely related to various cardiovascular diseases. Oxidative stress and apoptosis are involved in the progress of endothelial dysfunction. Irigenin (IR) has antioxidative properties. We investigated IR as a novel therapy for angiotensin… read more here.
Keywords: ang induced; apoptosis; viability; stress apoptosis ... See more keywords
Short‐term hypoxia upregulated Mas receptor expression to repress the AT1R signaling pathway and attenuate Ang II‐induced cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26440
Abstract: Hypertension‐stimulated cardiac hypertrophy and apoptosis play critical roles in the progression of heart failure. Our previous study suggested that hypertensive angiotensin II (Ang II) enhanced insulin‐like growth factor receptor II (IGF‐IIR) expression and cardiomyocyte apoptosis,… read more here.
Keywords: ang induced; apoptosis; signaling pathway; expression ... See more keywords
SP1‐SYNE1‐AS1‐miR‐525‐5p feedback loop regulates Ang‐II‐induced cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28131
Abstract: Cardiac hypertrophy (CH) has become a huge threat to human health. Recent years, long noncoding RNAs (lncRNAs) have been studied in human diseases, including CH. According to bioinformatics analysis, 10 lncRNAs possibly involved in the… read more here.
Keywords: ang induced; syne1 as1; as1; mir 525 ... See more keywords
Sulfatase 1 mediates the attenuation of Ang II‐induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2017.12.027
Abstract: &NA; Extracellular sulfatases, sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling and carcinogenesis. Chemokine CCL5 inhibits Ang II‐induced hypertensive mediators via angiotensin II (Ang II) type 2 receptor (AT2… read more here.
Keywords: ang induced; ccl5; hypertensive effects; induced hypertensive ... See more keywords
Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155754
Abstract: Extracellular sulfatases (sulfatase 1 and sulfatase 2) mediate up- or down-regulatory effects of cytokines on angiotensin II (Ang II)-induced expression of hypertensive mediators in hypertensive cells. The overproduction of transforming growth factor-β1 (TGF-β1) is associated… read more here.
Keywords: ang induced; hypertensive effects; tgf; shr vsmcs ... See more keywords
Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-β1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172549
Abstract: Recent studies have revealed critical roles of transforming growth factor-β1 (TGF-β1) and microRNA-132 (miR-132), a downstream mediator of TGF-β1, in the pathogenesis of cardiac remodeling. In this study, we tested whether the antiaging protein klotho… read more here.
Keywords: ang induced; induced cardiac; mir 132; growth factor ... See more keywords
LongShengZhi alleviated cardiac remodeling via upregulation microRNA-150-5p with matrix metalloproteinase 14 as the target.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115156
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE LongShengZhi capsule (LSZ), a traditional Chinese medicine, is used for treatment of patients with vascular diseases. LSZ reduced doxorubicin-induced heart failure by reducing production of reactive oxygen species and inhibiting inflammation anf apoptosis.… read more here.
Keywords: mir 150; upregulation; cardiac remodeling; ang induced ... See more keywords
Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.10.016
Abstract: &NA; Activation of soluble epoxide hydrolase (sEH) is associated with endothelial dysfunction in hypertension, though the underlying mechanisms are inadequately understood and the role of endoplasmic reticulum (ER) stress is yet to be studied in… read more here.
Keywords: ang induced; endothelium; stress; expression ... See more keywords
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00563-7
Abstract: Reduction of expression and activity of sirtuin 3 (SIRT3) contributes to the pathogenesis of cardiomyopathy via inducing mitochondrial injury and energy metabolism disorder. However, development of effective ways and agents to modulate SIRT3 remains a… read more here.
Keywords: ang induced; cardiac hypertrophy; induced cardiac; hypertrophy ... See more keywords
Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0923
Abstract: The mechanism of abdominal aortic aneurysm (AAA) has not been fully elucidated. In this study, we aimed to map the cellular heterogeneity, molecular alteration, and functional transformation of angiotensin (Ang) II-induced AAA in mice based… read more here.
Keywords: heterogeneity; ang induced; cell; induced aaa ... See more keywords
Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000713
Abstract: Abstract: Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II) induces cardiac inflammation and oxidative stress, which also is implicated in the pathophysiology of adverse collagen accumulation–induced remodeling. Kaempferol (KPF),… read more here.
Keywords: oxidative stress; ang induced; ang; inflammation oxidative ... See more keywords