Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0966-3
Abstract: Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer’s disease (AD). Moreover, activation of AT1 impairs the survival pathway phosphoinositide 3-kinase/protein kinase B (PI3K/Akt). Interestingly, the coupling between ACE2/Ang(1–7)/Mas… read more here.
Keywords: ang mas; ace2 ang; ace2; pi3k akt ... See more keywords
N-Acetyl-Seryl-Asparyl-Lysyl-Proline interaction with ACE2-Ang (1-7)-Mas axis attenuates pulmonary fibrosis in silicotic rats.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental physiology"
DOI: 10.1113/ep087515
Abstract: NEW FINDINGS What is the central question of this study? To explore the effects of Ac-SDKP on ACE2/Ang (1-7)/Mas axis in occurrence and progress of silicosis. What is the main finding and its importance? Ac-SDKP… read more here.
Keywords: silicosis; ace2 ang; ang mas; ang ... See more keywords
Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)–Mas on cerebral ischaemia injury
Sign Up to like & getrecommendations! Published in 2022 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2021-001396
Abstract: Background Postsynaptic density protein-95 (PSD95) plays an important role in cerebral ischaemia injury, but its mechanism needs further research. This study aimed to explore the role of PSD95 in (Ang-(1-7))-Mas-mediated cerebral ischaemia protection and its… read more here.
Keywords: density protein; postsynaptic density; psd95; ang mas ... See more keywords
Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.67042.14700
Abstract: Objective(s): We aimed to investigate the preventative effect of Qing Fei Hua Xian Decoction (QFHXD) against pulmonary fibrosis (PF) and its potential mechanisms. Materials and Methods: Bleomycin (BLM)-induced rats were respectively treated with 413.3, 826.6,… read more here.
Keywords: angiotensin; ang mas; ace; angii ... See more keywords
Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in cardiovascular medicine"
DOI: 10.31083/j.rcm2203083
Abstract: The renin-angiotensin system (RAS) helps to regulate cardiovascular function, the maintenance of electrolyte and fluid balance, and blood pressure. The RAS contains two axes; the angiotensin-converting enzyme/angiotensin II/Ang II type 1 receptors (ACE/Ang II/AT1) classic… read more here.
Keywords: ang mas; axis; glucose metabolism; ace2 ang ... See more keywords