Therapeutic targeting of the angiopoietin–TIE pathway
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DOI: 10.1038/nrd.2016.278
Abstract: The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological… read more here.
Keywords: tie pathway; targeting angiopoietin; therapeutic targeting; ang tie ... See more keywords
Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
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DOI: 10.1038/s41433-020-01377-x
Abstract: The angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development and maintenance. Its relevance to clinicians and basic scientists as a potential therapeutic target… read more here.
Keywords: vascular; choroidal vascular; retinal choroidal; ang tie ... See more keywords
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2036121
Abstract: ABSTRACT Introduction Several approaches have been investigated for treating wet age-related macular degeneration (w-AMD), diabetic macular edema (DME) and retinal vein occlusions (RVOs). The first-line treatment for these exudative retinal diseases consists of anti-vascular endothelial… read more here.
Keywords: angiopoietin tie; ang tie; tie pathway; retinal diseases ... See more keywords
Abstract 2611: Evaluation of ANG/TIE/hypoxia pathway genes and signatures as predictors of response to trebananib (AMG 386) in the neoadjuvant I-SPY 2 TRIAL for Stage II-III high-risk breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2611
Abstract: Background: The angiogenesis (ANG1/2) inhibitor trebananib (TR) was one of the experimental agents evaluated in I-SPY 2. In I-SPY 2, all patients received at least standard chemotherapy (paclitaxel followed by doxorubicin/cyclophosphamide: T->AC). HER2- patients were… read more here.
Keywords: arm; ang tie; response; genes signatures ... See more keywords
Ang–Tie Angiogenic Pathway Is Distinctively Expressed in Benign and Malignant Adrenocortical Tumors
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DOI: 10.3390/ijms23105579
Abstract: The differential diagnosis between adrenocortical adenomas (ACAs) and adrenocortical carcinomas (ACCs) relies on unspecific clinical, imaging and histological features, and, so far, no single molecular biomarker has proved to improve diagnostic accuracy. Similarly, prognostic factors… read more here.
Keywords: tie angiogenic; adrenocortical tumors; vegf; expression ... See more keywords
Efforts to Find Targets Involving Angiogenesis: Step to Improve the Efficacy of Target Therapy in the Era of Colorectal Cancer Treatment
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Coloproctology"
DOI: 10.3393/ac.2017.33.1.1
Abstract: Continuous efforts have been made to find an effective treatment to improve oncologic outcomes for patients with colorectal cancer. These efforts have accomplished a noticeable achievement by using biomarker-based approaches. Antiangiogenic drugs that target the… read more here.
Keywords: ang tie; treatment; colorectal cancer; target ... See more keywords