New soluble angiopoietin analog of Hepta‐ANG1 prevents pathological vascular leakage
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27580
Abstract: Vascular leak is a key driver of organ injury in diseases, and strategies that reduce enhanced permeability and vascular inflammation are promising therapeutic targets. Activation of the angiopoietin‐1 (ANG1)‐Tie2 tyrosine kinase signaling pathway is an… read more here.
Keywords: vascular leakage; hepta ang1; new soluble; ang1 ... See more keywords
Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.210
Abstract: Supplemental Angiopoietin 1 (Ang1) exerts its therapeutic potential on microvascular regression-associated diseases, and this potential is linked with the function of hematopoietic stem cells (HSCs). However, the underlying mechanisms of the effect of enhanced angiogenesis… read more here.
Keywords: ang1; impairs microenvironment; senescence hscs; comp ang1 ... See more keywords
Effect of HIV-1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.121.021397
Abstract: Background Individuals infected with HIV have an increased risk of developing cardiovascular disease; yet, the underlying mechanisms remain unknown. Recent evidence has implicated the Tie-2 tyrosine kinase receptor system and its associated ligands ANG1 (angiopoietin… read more here.
Keywords: ang2; hiv infection; ang1; dysfunction ... See more keywords