Myocardial Angiotensin Metabolism in End-Stage Heart Failure.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2021.01.052
Abstract: BACKGROUND The myocardium exhibits an adaptive tissue-specific renin-angiotensin system (RAS), and local dysbalance may circumvent the desired effects of pharmacologic RAS inhibition, a mainstay of heart failure with reduced ejection fraction (HFrEF) therapy. OBJECTIVES This… read more here.
Keywords: angiii; heart; heart failure; angiotensin ... See more keywords
Fibulin-3 affects vascular endothelial function and is regulated by angiotensin II.
Sign Up to like & getrecommendations! Published in 2020 at "Microvascular research"
DOI: 10.1016/j.mvr.2020.104043
Abstract: OBJECTIVE The aim of the present study was to investigate the effect of fibulin-3 on vascular endothelial function, and to explore the relevant underlying mechanism with regard to the involvement of angiotensin II (AngII). METHODS… read more here.
Keywords: endothelial function; vascular endothelial; serum fibulin; fibulin ... See more keywords
Label‐free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time‐resolved G‐protein activity and distinct AngII and AngIIIIV responses
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.06.027
Abstract: ABSTRACT Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein‐coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein… read more here.
Keywords: type receptor; response; label free; angiotensin ... See more keywords
Sex-dependent effects of ERAP1 deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-019-0231-7
Abstract: Nature reviews | Nephrology the renin–angiotensin system regulates blood pressure (BP) and mounting evidence indicates that biological sex affects the pathways activated by these hormonal mediators. Now, Jose romero and colleagues report a sex bias… read more here.
Keywords: nephrology; biological sex; sex; erap1 deficiency ... See more keywords
Plasma heme-induced renal toxicity is related to a capillary rarefaction
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40156
Abstract: Severe hypertension can lead to malignant hypertension (MH) with renal thrombotic microangiopathy and hemolysis. The role of plasma heme release in this setting is unknown. We aimed at evaluating the effect of a mild plasma… read more here.
Keywords: plasma heme; heme; toxicity; rarefaction ... See more keywords
Targeting HSP90 attenuates angiotensin II-induced adventitial remodeling via suppression of mitochondrial fission.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular research"
DOI: 10.1093/cvr/cvz194
Abstract: AIMS Adventitial remodeling presenting with the phenotypic switch of adventitial fibroblasts (AFs) to myofibroblasts (MFs) is reportedly involved in the evolution of several vascular diseases, including hypertension. In our previous study, we reported that heat… read more here.
Keywords: fission; mitochondrial fission; adventitial remodeling; hsp90 inhibition ... See more keywords
P1661The myocardial tissue Renin-Angiotensin-System (RAS) of the failing heart
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0419
Abstract: Prognosis of patients with HFrEF remains poor despite recent advances in pharmacologic therapy as the introduction of the angiotensin-receptor neprilysin-inhibitor (ARNI). The Renin-Angiotensin-System (RAS) is dysregulated in HF with elevated AngII levels as a central… read more here.
Keywords: failing heart; heart; myocardial tissue; tissue ... See more keywords
THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN THE PREGNANT RAT
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000838428.32272.52
Abstract: Objective: Preeclampsia is the leading cause of maternal and fetal morbidity and mortality in the United States, affecting ~2–5% of all pregnancies. Women with a history of preeclampsia have a 4-fold increased risk for developing… read more here.
Keywords: aldosterone; angiotensin aldosterone; aldosterone system; angii ... See more keywords
FRI0396 The atm kinase and pten, drive myofibroblasts differentiation by activating the tgfΒ autocrine loop
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5224
Abstract: Background Pulmonary fibrosis is a major cause of mortality in scleroderma (SSc) and Idiopathic Pulmonary Fibrosis (IPF). Fibrosis is driven by Inappropriate myofibroblast differentiation and persistence. Understanding this process, is vital for developing an effective… read more here.
Keywords: akt; atm kinase; activation; angii ... See more keywords
Role of scleraxis in angiotensin II-induced cardiac fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5725178
Abstract: Cardiac fibrosis involves the activation and conversion of fibroblasts to myofibroblasts in response to pathophysiological stresses, resulting in structural and functional remodeling of the heart leading to heart failure and death. Although it affects millions… read more here.
Keywords: cardiac fibrosis; expression; physiology; scleraxis ... See more keywords
Angiotensin-II impairs the cellular antioxidant defense capacity in the hypothalamic cardio regulatory nucleus of spontaneously hypertensive rats contributing to hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734703
Abstract: Oxidative stress is a central mechanism underlying Angiotensin II (AngII)-induced enhanced sympathetic outflow within brain cardio-regulatory nuclei in neurogenic hypertension. Yet, a causal association between AngII, Nrf2 (nuclear factor erythroid 2-related factor 2 - the… read more here.
Keywords: nucleus cytosol; hypertension; expression; physiology ... See more keywords