Role of PLD−PKCζ signaling axis in p47phox phosphorylation for activation of NADPH oxidase by angiotensin II in pulmonary artery smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11145
Abstract: We sought to determine the mechanism by which angiotensin II (ANGII) stimulates NADPH oxidase‐mediated superoxide (O2.−) production in bovine pulmonary artery smooth muscle cells (BPASMCs). ANGII‐induced increase in phospholipase D (PLD) and NADPH oxidase activities… read more here.
Keywords: oxidase; pkc; pld; angii induced ... See more keywords
Stromal cell-derived factor-1 exerts opposing roles through CXCR4 and CXCR7 in angiotensin II-induced adventitial remodeling.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.030
Abstract: Recent studies have emphasized the role of vascular adventitia inflammation and immune response in hypertension. It has been reported that stromal cell-derived factor-1 (SDF-1) plays various biological functions through its receptors C-X-C motif chemokine receptor… read more here.
Keywords: angii induced; sdf; induced adventitial; cxcr4 cxcr7 ... See more keywords
Novel preventive effect of isorhamnetin on electrical and structural remodeling in atrial fibrillation.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220319
Abstract: Isorhamnetin, a natural flavonoid, has strong antioxidant and antifibrotic effects, and a regulatory effect against Ca2+-handling. Atrial remodeling due to fibrosis and abnormal intracellular Ca2+ activities contributes to initiation and persistence of atrial fibrillation (AF).… read more here.
Keywords: isorhamnetin; atrial fibrillation; angii induced; effect isorhamnetin ... See more keywords
Qiqilian ameliorates vascular endothelial dysfunction by inhibiting NLRP3-ASC inflammasome activation in vivo and in vitro.
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical biology"
DOI: 10.1080/13880209.2023.2208617
Abstract: CONTEXT Previous studies have highlighted significant therapeutic effects of Qiqilian (QQL) capsule on hypertension in spontaneously hypertensive rats (SHRs); however, its underlying molecular mechanism remains unclear. OBEJECTIVE We investigated the potential mechanism by which QQL… read more here.
Keywords: group; angii induced; nlrp3 asc; endothelial dysfunction ... See more keywords
Abstract 053: Differential Effects of LRP1 in AngII-induced Ascending Aortic PathologiesBetween Male and Female Mice: Lack of Association With Elastin Fragmentation
Sign Up to like & getrecommendations! Published in 2018 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvb.38.suppl_1.053
Abstract: Objective: Low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane protein, is important in maintaining elastin fiber integrity of the aortic wall. Smooth muscle cells (SMCs) of ... read more here.
Keywords: effects lrp1; abstract 053; differential effects; 053 differential ... See more keywords
Edaravone Attenuated Angiotensin II-Induced Atherosclerosis and Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12081117
Abstract: Background: The aim of the study was to define whether edaravone, a free-radical scavenger, influenced angiotensin II (AngII)-induced atherosclerosis and abdominal aortic aneurysms (AAAs) formation. Methods: Male apolipoprotein E-deficient mice (8–12 weeks old) were fed… read more here.
Keywords: apolipoprotein deficient; deficient mice; angii induced; mice ... See more keywords
Celastrol Supplementation Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040603
Abstract: Background: Abdominal aortic aneurysms (AAAs) are permanent dilations of the abdominal aorta with 4–5 times greater prevalence in males than in females. The aim of this study is to define whether Celastrol, a pentacyclic triterpene… read more here.
Keywords: supplementation; celastrol supplementation; abdominal aortic; angii induced ... See more keywords
Cilostazol Attenuates AngII-Induced Cardiac Fibrosis in apoE Deficient Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169065
Abstract: Cardiac fibrosis is characterized by the net accumulation of extracellular matrix in the myocardium and is an integral component of most pathological cardiac conditions. Cilostazol, a selective inhibitor of phosphodiesterase type III with anti-platelet, anti-mitogenic,… read more here.
Keywords: cilostazol; cardiac fibrosis; angii induced; mice ... See more keywords
SLC26A4-AS1 Aggravates AngII-induced Cardiac Hypertrophy by Enhancing SLC26A4 Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Arquivos brasileiros de cardiologia"
DOI: 10.36660/abc.20210933
Abstract: BACKGROUND It has been reported that solute carrier family 26 members 4 antisense RNA 1 (SLC26A4-AS1) is highly related to cardiac hypertrophy. OBJECTIVE This research aims to investigate the role and specific mechanism of SLC26A4-AS1… read more here.
Keywords: slc26a4 as1; angii induced; cardiac hypertrophy;
Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2017.2924
Abstract: Angiotensin II (AngII)-induced production of inflammatory factors and proliferation in vascular smooth muscle cells (VSMCs) play an important role in the progression of atherosclerotic plaques. Growing evidence has demonstrated that activation of peroxisome proliferator-activated receptor-γ (PPAR-γ)… read more here.
Keywords: ppar; production; angii induced; ppar activity ... See more keywords