Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage
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DOI: 10.1002/2211-5463.12621
Abstract: Angiogenesis plays a critical role in embryo development, tissue repair, tumor growth and wound healing. In the present study, we investigated the role of the serine/threonine kinase Akt in angiogenesis. Silencing of Akt1 in human… read more here.
Keywords: angiogenesis; mural cell; akt1; cell coverage ... See more keywords
Bioactive Poly(octanediol-citrate-polyglycol) Accelerates Skin Regeneration through M2 Polarization Immunomodulating and Early Angiogenesis.
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DOI: 10.1002/adhm.202101931
Abstract: The inhibition of inflammation and the promotion of early angiogenesis have been paid much attention in skin tissue engineering. Citric acid-based biomaterials are widely used in tissue engineering due to their bioactive structure and biocompatibility,… read more here.
Keywords: citrate; angiogenesis; polarization; skin regeneration ... See more keywords
A ROS‐Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro‐Angiogenesis for Efficient Treatment of Myocardial Infarction
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DOI: 10.1002/adhm.202200990
Abstract: Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant pathogenesis of early myocardial infarction (MI). However, only a few agents or strategies have been developed to improve mitochondrial dysfunction for the effective MI… read more here.
Keywords: hydrogel; liposomal composite; mitochondrial dysfunction; treatment ... See more keywords
Dapagliflozin‐Loaded Exosome Mimetics Facilitate Diabetic Wound Healing by HIF‐1α‐Mediated Enhancement of Angiogenesis
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DOI: 10.1002/adhm.202202751
Abstract: Angiogenesis plays a critical role in diabetic wound healing. However, no effective strategies have been developed to target endothelial cells (ECs) to facilitate diabetic wound healing. Dapagliflozin (DA) as a sodium‐glucose linked transporter 2 (SGLT2)… read more here.
Keywords: wound healing; facilitate diabetic; diabetic wound; angiogenesis ... See more keywords
Hyaluronic Acid Role in Biomaterials Prevascularization
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DOI: 10.1002/adhm.202402045
Abstract: Tissue vascularization is a major bottleneck in tissue engineering. In this review, the state of the art on the intricate role of hyaluronic acid (HA) in angiogenesis is explored. HA plays a twofold role in… read more here.
Keywords: vascularization; role; tissue engineering; hyaluronic acid ... See more keywords
Tissue‐Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria‐Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis
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DOI: 10.1002/adhm.202404889
Abstract: Effective treatment of diabetic wounds remains challenging because of multidrug‐resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue‐adhesive and antibacterial hydrogel incorporating MXene and deferoxamine (DFO)‐loaded microspheres is developed… read more here.
Keywords: diabetic wound; hydrogel; angiogenesis; wound healing ... See more keywords
Silicon‐Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering
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DOI: 10.1002/advs.201800776
Abstract: Abstract The enhancement of adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and sufficient vascularization remain great challenges for the successful reconstruction of engineered adipose tissue. Here, the bioactive effects of silicon (Si) ions… read more here.
Keywords: angiogenesis; adipogenic differentiation; tissue; adipose tissue ... See more keywords
Long‐Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy
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DOI: 10.1002/advs.202004226
Abstract: Abstract Wound healing is a well‐coordinated process, necessitating efficient formation of new blood vessels. Vascularization defects are therefore a major risk factor for chronic, non‐healing wounds. The dynamics of mammalian tissue revascularization, vessel maturation, and… read more here.
Keywords: large scale; wound angiogenesis; angiogenesis; microscopy ... See more keywords
DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3
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DOI: 10.1002/advs.202105226
Abstract: The ability of melanoma to acquire metastasis through the induction of angiogenesis is one of the major causes of skin cancer death. Here, it is found that high transcript levels of DEP domain containing 1B… read more here.
Keywords: metastasis; ubiquitin ligase; depdc1b; scube3 ... See more keywords
Targeting Grancalcin Accelerates Wound Healing by Improving Angiogenesis in Diabetes
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DOI: 10.1002/advs.202305856
Abstract: Chronic diabetic wounds are a serious complication of diabetes and often result in limb amputations and confer high mortality rates. The proinflammatory secretome in the wound perpetuates defective neovascularization and contributes to dysregulated tissue repair.… read more here.
Keywords: accelerates wound; grancalcin; angiogenesis; wound healing ... See more keywords
Chitosan/Fibroin Biopolymer‐Based Hydrogels for Potential Angiogenesis in Developing Chicks and Accelerated Wound Healing in Mice
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DOI: 10.1002/bip.23633
Abstract: Potential therapies for wound management remain one of the most challenging affairs to date. Biopolymer hydrogels possess inherent properties that facilitate the healing of damaged tissue by creating a supportive and hydrated environment. Chitosan/fibroin hydrogels… read more here.
Keywords: healing mice; biopolymer; chitosan fibroin; wound healing ... See more keywords