The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.05.012
Abstract: BACKGROUND AND AIMS Peripheral arterial disease (PAD) is an important cause of morbidity and mortality with little effective medical treatment currently available. Nitric oxide (NO) is crucially involved in organ perfusion, tissue protection and angiogenesis.… read more here.
Keywords: angiogenesis arteriogenesis; mpc; mpc 1011; donor mpc ... See more keywords
Abstract 888: Exosomes Derived From Endothelial Progenitor Cells Modulate Flow-Induced Remodeling and Increase Angiogenesis/Arteriogenesis in Mesenteric Arteries of Mice
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.888
Abstract: Exosomes are key regulators of cell-to-cell communication, becoming valuable tool as disease biomarker and in the development of new therapeutic strategies. We aimed to determine the role of endothelial progenitor cell (EPC)-derived exosomes (EXO) in… read more here.
Keywords: angiogenesis arteriogenesis; endothelial progenitor; flow; mesenteric arteries ... See more keywords
Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis
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DOI: 10.3389/fphys.2019.01618
Abstract: Vasculogenesis, angiogenesis and arteriogenesis represent three crucial mechanisms involved in the formation and maintenance of the vascular network in embryonal and post-natal life. It has long been known that endothelial Ca2+ signals are key players… read more here.
Keywords: trp channels; angiogenesis arteriogenesis; vasculogenesis;
Interdependence of Angiogenesis and Arteriogenesis in Development and Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073879
Abstract: The structure of arterial networks is optimized to allow efficient flow delivery to metabolically active tissues. Optimization of flow delivery is a continuous process involving synchronization of the structure and function of the microcirculation with… read more here.
Keywords: angiogenesis arteriogenesis; development; interdependence angiogenesis; development disease ... See more keywords