Clinical Efficacy and Safety of Angiogenesis Inhibitors: Sex Differences and Current Challenges.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab096
Abstract: Vasoactive molecules, such as vascular endothelial growth factor (VEGF) and endothelins, share cytokine-like activities and regulate endothelial cell (EC) growth, migration and inflammation. Some endothelial mediators and their receptors are targets for currently approved angiogenesis… read more here.
Keywords: angiogenesis; current challenges; angiogenesis inhibitors; sex differences ... See more keywords
Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0221796
Abstract: Their optical clarity as larvae and embryos, small size, and high fecundity make zebrafish ideal for whole animal high throughput screening. A high-throughput drug discovery platform (HTP) has been built to perform fully automated screens… read more here.
Keywords: angiogenesis; angiogenesis inhibitors; discovery angiogenesis; protocol development ... See more keywords
Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16942
Abstract: The role of paracrine Hepatocyte Growth Factor (HGF) in the resistance to angiogenesis inhibitors (AIs) is hidden in xenograft models because mouse HGF fails to fully activate human MET. To uncover it, we compared the… read more here.
Keywords: colorectal; angiogenesis inhibitors; stroma derived; colorectal cancer ... See more keywords
Angiogenesis Inhibitors and Immunomodulation in Renal Cell Cancers: The Past, Present, and Future
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061406
Abstract: Simple Summary In their advanced stages, the mainstay of kidney cancer treatment is with medications such as targeted or immune therapies. Breakthroughs in scientific understanding of cancer drug development have led to substantial improvements in… read more here.
Keywords: cell; renal cell; inhibitors immunomodulation; drug ... See more keywords
Analysis of Efficacy-To-Safety Ratio of Angiogenesis-Inhibitors Based Therapies in Ovarian Cancer: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13061040
Abstract: (1) Background: Among new anti-angiogenesis agents being developed and ever-changing guidelines indications, the question of the benefits/safety ratio remains unclear. (2) Methods: We performed a systematic review combined with a meta-analysis of 23 randomized controlled… read more here.
Keywords: meta analysis; safety ratio; systematic review; analysis ... See more keywords
Potential Therapeutic Strategies for Lung and Breast Cancers through Understanding the Anti-Angiogenesis Resistance Mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21020565
Abstract: Breast and lung cancers are among the top cancer types in terms of incidence and mortality burden worldwide. One of the challenges in the treatment of breast and lung cancers is their resistance to administered… read more here.
Keywords: angiogenesis; breast; angiogenesis inhibitors; therapeutic strategies ... See more keywords