Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.03.009
Abstract: Glioblastoma multiforme (GBM) is a lethal and highly vascular type of brain tumor. We previously reported that isolinderalactone enhances GBM apoptosis in vitro and in vivo, but its role in tumor angiogenesis is unknown. Here,… read more here.
Keywords: microfluidic chip; angiogenic activity; glioblastoma; activity ... See more keywords
Towards anti-angiogenic activity of NiFe2O4 nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "Ceramics International"
DOI: 10.1016/j.ceramint.2021.02.191
Abstract: Abstract In this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 hours with (S- NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and… read more here.
Keywords: nife2o4; angiogenic activity; nife2o4 nanoparticles; anti angiogenic ... See more keywords
Angiogenic activity in vivo of the particulate matter (PM10).
Sign Up to like & getrecommendations! Published in 2017 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2017.02.036
Abstract: BACKGROUND Particulate matter (PM) is the most efficient vehicle for the inhalation and absorption of toxic substances into the body. METHOD The present study was aimed at testing the hypothesis that PM10 samples collected on… read more here.
Keywords: particulate matter; activity vivo; pm10; angiogenic activity ... See more keywords
Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF-α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173008
Abstract: Hepatopulmonary syndrome (HPS) is a severe complication of hepatic cirrhosis, which is characterized by hypoxia, intrapulmonary vasodilation, inflammation, and angiogenesis. In this study, we aimed to investigate the regulatory effects of diosmin (DS) on selected… read more here.
Keywords: akt; angiogenic activity; vegf igf; pi3k akt ... See more keywords
Anti-Angiogenic Activity of Rotenoids from the Stems of Derris trifoliata.
Sign Up to like & getrecommendations! Published in 2018 at "Planta medica"
DOI: 10.1055/s-0044-100797
Abstract: The plants in the genus Derris have proven to be a rich source of rotenoids, of which cytotoxic effect against cancer cells seem to be pronounced. However, their effect on angiogenesis playing a crucial role… read more here.
Keywords: derris trifoliata; angiogenic activity; effect; cancer ... See more keywords
In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s252681
Abstract: Introduction The aim of this study was to screen the leading compounds of natural origin with anti-angiogenic potential and to investigate their anti-angiogenic mechanism preliminarily. Materials and Methods An initial screening of 240 compounds from… read more here.
Keywords: angiogenic activity; natural products; dimethyl ether; anti angiogenic ... See more keywords
Anti-Angiogenic Activity of Drugs in Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15071990
Abstract: Simple Summary The “angiogenic switch” contributes to the transition from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM), sustaining disease progression and drug resistance. In this review, we describe the anti-angiogenic activity of… read more here.
Keywords: anti angiogenic; multiple myeloma; angiogenic activity;
The oncometabolite d‑2‑hydroxyglutarate induces angiogenic activity through the vascular endothelial growth factor receptor 2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of oncology"
DOI: 10.3892/ijo.2018.4649
Abstract: The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d‑ or l‑forms of 2‑hydroxyglutarate (2HG) from α‑ketoglutarate… read more here.
Keywords: angiogenic activity; vascular endothelial; endothelial growth; growth factor ... See more keywords
Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.9155
Abstract: Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in… read more here.
Keywords: anti angiogenic; activity middle; angiogenic activity; lamiaceae family ... See more keywords
RK-270D and E, oxindole derivatives from Streptomyces sp. with anti-angiogenic activity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.2110.10039
Abstract: A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structure of 1 and 2 were determined by… read more here.
Keywords: oxindole derivatives; streptomyces anti; anti angiogenic; angiogenic activity ... See more keywords
Anti-Angiogenic Activity of Flunarizine by In Ovo, In Vitro, and In Vivo Assays
Sign Up to like & getrecommendations! Published in 2019 at "Turkish Journal of Pharmaceutical Sciences"
DOI: 10.4274/tjps.galenos.2018.29981
Abstract: Objectives: The involvement of T-type calcium channels in cell proliferation and the role of sodium channels in cell migration have been extensively studied in angiogenesis. In the present study, flunarizine, a dual sodium/calcium channel blocker;… read more here.
Keywords: angiogenic activity; vivo; proliferation; migration ... See more keywords