Nanoparticle Delivery of MnO2 and Anti-angiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c08473
Abstract: Anti-angiogenic therapy is widely administered in many cancers, and the anti-angiogenic drug sorafenib offers moderate benefits in advanced hepatocellular carcinoma (HCC). However, anti-angiogenic therapy can also lead to hypoxia-driven angiogenesis and immunosuppression in the tumor… read more here.
Keywords: hepatocellular carcinoma; hypoxia driven; angiogenic therapy; anti angiogenic ... See more keywords
Optimal control methods for drug delivery in cancerous tumour by anti-angiogenic therapy and chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "IET systems biology"
DOI: 10.1049/syb2.12010
Abstract: There are numerous mathematical models simulating the behaviour of cancer by considering variety of states in different treatment strategies, such as chemotherapy. Among the models, one is developed which is able to consider the blood… read more here.
Keywords: angiogenic therapy; control; drug; cancerous tumour ... See more keywords
Targeting endothelial cell metabolism in cancerous microenvironment: a new approach for anti-angiogenic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2116033
Abstract: Abstract Anti-angiogenic therapy is a practical approach to managing diseases with increased angiogenesis, such as cancer, maculopathies, and retinopathies. Considering the fundamental gaps in the knowledge of the vital pathways involved in angiogenesis and its… read more here.
Keywords: angiogenesis; metabolism; angiogenic therapy; anti angiogenic ... See more keywords
VEGFR2 and ITGA polymorphisms as novel predictors of therapeutic response and toxicities for pediatric and young adult sarcoma undergoing anti-angiogenic therapy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz433.003
Abstract: Abstract Background The impact of germline mutations of the angiogenesis pathways on the therapeutic response has been extensively studied for the carcinoma population. However, such information is almost unknown for pediatric and young adult’s sarcoma,… read more here.
Keywords: sarcoma; angiogenic therapy; response; therapy ... See more keywords
Effect of mast cells on efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme b.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.11522
Abstract: 11522Background: Resistance towards anti-angiogenic therapy (AAT) still represents a substantial clinical challenge. As mast cell (MC) density is known to correlate with tumor angiogenesis, we anal... read more here.
Keywords: mast cells; effect mast; anti angiogenic; angiogenic therapy ... See more keywords
The role of tumor microenvironment in resistance to anti-angiogenic therapy
Sign Up to like & getrecommendations! Published in 2018 at "F1000Research"
DOI: 10.12688/f1000research.11771.1
Abstract: Anti-angiogenic therapy has been demonstrated to increase progression-free survival in patients with many different solid cancers. Unfortunately, the benefit in overall survival is modest and the rapid emergence of drug resistance is a significant clinical… read more here.
Keywords: tumor microenvironment; anti angiogenic; resistance; angiogenic therapy ... See more keywords
Analysis and Optimal Control in the Cancer Treatment Model with Combining Radio and Anti-angiogenic Therapy
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Computing"
DOI: 10.12962/j24775401.v3i2.2288
Abstract: Cancer is a disease characterized by uncontrolled cell division and the ability of these cells to invade other tissues, either tissue next to them or not. Cancer treatment process is very diverse. The issue in… read more here.
Keywords: cancer; treatment; anti angiogenic; angiogenic therapy ... See more keywords
Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185065
Abstract: Glioblastoma (GBM) is a rapidly progressive brain cancer that exploits the neural microenvironment, and particularly blood vessels, for selective growth and survival. Anti-angiogenic agents such as the vascular endothelial growth factor-A (VEGF-A) blocking antibody bevacizumab… read more here.
Keywords: anti angiogenic; growth; angiogenic therapy; recurrence ... See more keywords
Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18445
Abstract: Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypoxia-induced… read more here.
Keywords: angiogenic therapy; hypoxic cancer; hypoxia; anti angiogenic ... See more keywords
Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03107
Abstract: Radiotherapy has been used for the treatment of cancer for over a century. Throughout this period, the therapeutic benefit of radiotherapy has continuously progressed due to technical developments and increased insight in the biological mechanisms… read more here.
Keywords: angiogenic therapy; combining radiotherapy; radiotherapy; cancer ... See more keywords
YKL-39 as a Potential New Target for Anti-Angiogenic Therapy in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02930
Abstract: YKL-39 belongs to the evolutionarily conserved family of Glyco_18-containing proteins composed of chitinases and chitinase-like proteins. Chitinase-like proteins (CLPs) are secreted lectins that lack hydrolytic activity due to the amino acid substitutions in their catalytic… read more here.
Keywords: angiogenic therapy; new target; cancer; anti angiogenic ... See more keywords