Multivalent Angiomotin‐like 1 and Yes‐associated protein form a dynamic complex
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DOI: 10.1002/pro.4295
Abstract: Multivalent complexes formed between the cancer‐promoting transcriptional co‐activator, Yes‐associated protein (YAP), and proteins containing short linear motifs of type PPxY modulate cell proliferation and are attractive therapeutic targets. However, challenges producing PPxY polypeptides containing the… read more here.
Keywords: amotl1; yes associated; ppxy; angiomotin like ... See more keywords
Angiomotin-like 2 interacts with and negatively regulates AKT
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DOI: 10.1038/onc.2017.101
Abstract: Angiomotin-like 2 (AMOTL2) is a member of Angiomotin family proteins, which are potent inhibitors for the Hippo pathway effector YAP. However, additional cellular functions of AMOTL2 besides YAP inhibition are largely unknown. Here, we reported… read more here.
Keywords: yap akt; angiomotin like; negatively regulates; regulates akt ... See more keywords