Mining the role of angiopoietin‐like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3100
Abstract: The indistinctive effects of antiangiogenesis agents in gastric cancer (GC) can be attributed to multifaceted gene dysregulation associated with angiogenesis. Angiopoietin‐like (ANGPTL) proteins are secreted proteins regulating angiogenesis. They are also involved in inflammation and… read more here.
Keywords: mining role; gastric cancer; role angiopoietin; cancer ... See more keywords
The Clinical Role of Angiopoietin-Like Protein 3 in Evaluating Coronary Artery Disease in Patients with Obstructive Sleep Apnea
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-06991-1
Abstract: Purpose Hyperlipidemia is the most important early atherosclerosis and coronary artery disease (CAD) indicator. Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 are lipid dysfunction markers that may be linked to CAD. We investigated whether these… read more here.
Keywords: cad; coronary artery; patients obstructive; obstructive sleep ... See more keywords
Angiopoietin-like 3 Is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2018.03.040
Abstract: PURPOSE To investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM). DESIGN Cross-sectional study. METHODS Serum levels of ANGPTL3,… read more here.
Keywords: retinopathy; vegf; angptl3 angptl4; biomarker ... See more keywords
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Lipid Research"
DOI: 10.1016/j.jlr.2021.100112
Abstract: High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3… read more here.
Keywords: angptl3; inhibition; endothelial lipase; hdl ... See more keywords
Circulating and tissue specific transcription of angiopoietin-like protein 4 in human Type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154192
Abstract: AIMS Obesity is associated with adipose tissue (AT) dysfunction marked by cellular hypertrophy, inflammation, hypoxia and fibrosis. Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase which regulates triglyceride storage. Recently, inhibition of ANGPTL4 has been suggested… read more here.
Keywords: protein; angptl4; like protein; tissue ... See more keywords
Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214888120
Abstract: Significance Aggressive tumors often die from the inside out, a process called necrotic cell death. Necrosis is associated with dissemination of cancer cells but how necrosis promotes tumor dissemination is not understood. Here, we used… read more here.
Keywords: necrotic core; angiopoietin like; dissemination; tumor ... See more keywords
Angiopoietin-Like Protein Responses to Pecan-Enriched Diets Versus a Nut-Excluded Diet.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal food"
DOI: 10.1089/jmf.2022.0034
Abstract: Daily pecan consumption improves fasting and postprandial triglycerides, but its effect on angiopoietin-like proteins (ANGPTLs) is unknown. The objective of this study was to investigate the impact of daily pecan consumption for 8 weeks on… read more here.
Keywords: daily pecan; angiopoietin like; postprandial angptl3; fasting postprandial ... See more keywords
RNAi inhibition of angiopoietin-like protein 3 (ANGPTL3) with ARO-ANG3 mimics the lipid and lipoprotein profile of familial combined hypolipidemia
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3331
Abstract: Elevated LDL-C and triglyceride rich lipoproteins (TRLs) are independent risk factors for cardiovascular disease (CVD). Genetic deficiency of angiopoietin-like protein 3 (ANGPTL3) is associated with reduced circulating levels of LDL-C, triglycerides (TGs), VLDL-C, HDL-C and… read more here.
Keywords: protein angptl3; ang3; tgs vldl; like protein ... See more keywords
Rare protective variants and glaucoma-relevant cell stressors modulate angiopoietin-like 7 expression.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddad083
Abstract: Rare missense and nonsense variants in the Angiopoietin-like 7 (ANGPTL7) gene confer protection from primary open-angle glaucoma (POAG), though the functional mechanism remains uncharacterized. Interestingly, larger variant effect size strongly correlates with in silico predictions… read more here.
Keywords: cell stressors; expression; protective variants; angiopoietin like ... See more keywords
Targeting angiopoietin‐like 3 in atherosclerosis: From bench to bedside
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.1111/dom.14450
Abstract: Atherosclerotic cardiovascular disease (ASCVD) is the largest cause of morbidity and mortality worldwide. Lipid‐lowering therapies are the current major cornerstone of ASCVD management. Statins, ezetimibe, fibrates and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors effectively… read more here.
Keywords: atherosclerosis bench; like atherosclerosis; targeting angiopoietin; bench bedside ... See more keywords
Angiopoietin‐2 and angiopoietin‐like 4 protein provide prognostic information in patients with suspected acute coronary syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13339
Abstract: Plasma levels of angiopoietin‐2 (ANGPT2) and angiopoietin‐like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a hospitalized Norwegian patient cohort (n = 871) with suspected acute… read more here.
Keywords: suspected acute; like protein; acute coronary; angiopoietin ... See more keywords