Therapeutic targeting of the angiopoietin–TIE pathway
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DOI: 10.1038/nrd.2016.278
Abstract: The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular permeability and pathological vascular remodelling during inflammation, tumour angiogenesis and metastasis. Drugs that target the ANG–TIE pathway are in clinical development for oncological and ophthalmological… read more here.
Keywords: tie pathway; targeting angiopoietin; therapeutic targeting; ang tie ... See more keywords
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases
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DOI: 10.1080/14728222.2022.2036121
Abstract: ABSTRACT Introduction Several approaches have been investigated for treating wet age-related macular degeneration (w-AMD), diabetic macular edema (DME) and retinal vein occlusions (RVOs). The first-line treatment for these exudative retinal diseases consists of anti-vascular endothelial… read more here.
Keywords: angiopoietin tie; ang tie; tie pathway; retinal diseases ... See more keywords
THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES: A REVIEW [67/135 characters].
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DOI: 10.1097/iae.0000000000003003
Abstract: PURPOSE To provide a concise overview for ophthalmologists and practicing retina specialists of available clinical evidence of manipulating the angiopoietin/tyrosine kinase with immunoglobulin-like and endothelial growth factor-like domains (Tie) pathway and its potential as a… read more here.
Keywords: tie pathway; angiopoietin tie; vascular diseases; pathway retinal ... See more keywords
Advanced Glycation End-Products and Hyperglycemia Increase Angiopoietin-2 Production by Impairing Angiopoietin-1-Tie-2 System
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DOI: 10.1155/2019/6198495
Abstract: The angiopoietin-Tie-2 system plays a crucial role in the maintenance of endothelial integrity. Hyperglycemia and advanced glycation end-products (AGEs) are involved in endothelial cell dysfunction responsible of the pathogenesis of microvascular complications of diabetes. Here,… read more here.
Keywords: tie system; angiopoietin tie; production;
The Angiopoietin-2 and TIE Pathway as a Therapeutic Target for Enhancing Antiangiogenic Therapy and Immunotherapy in Patients with Advanced Cancer
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DOI: 10.3390/ijms21228689
Abstract: Despite significant advances made in cancer treatment, the development of therapeutic resistance to anticancer drugs represents a major clinical problem that limits treatment efficacy for cancer patients. Herein, we focus on the response and resistance… read more here.
Keywords: therapy; treatment; efficacy; resistance ... See more keywords