Assessment of Vascular Dysfunction and Inflammation Induced by Angiotensin II in Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_30
Abstract: Vascular inflammation in cardiovascular diseases is recognized to be linked with immune cell activation. Recruitment of immune cells into the vessel wall is an early step in angiotensin II-induced vascular dysfunction and arterial hypertension. Exploring… read more here.
Keywords: angiotensin induced; inflammation; assessment vascular; vascular dysfunction ... See more keywords
ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.05.032
Abstract: Our aim was to examine the effects of ASB17061, an orally active novel chymase inhibitor, on angiotensin II-induced abdominal aortic aneurysm (AAA) in apolipoprotein E-deficient mice. Oral administration of ASB17061 (10 mg/kg) significantly suppressed angiotensin II-induced… read more here.
Keywords: chymase; novel chymase; angiotensin induced; induced abdominal ... See more keywords
Peptidyl-prolyl isomerase Pin1 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in ApoE-/- mice.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.12.006
Abstract: Peptidyl-prolyl isomerase Pin1 has been reported to be associated with endothelial dysfunction. However, the role of smooth muscle Pin1 in the vascular system remains unclear. Here, we examined the potential function of Pin1 in smooth… read more here.
Keywords: isomerase pin1; angiotensin induced; peptidyl prolyl; formation ... See more keywords
Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and experimental hypertension"
DOI: 10.1080/10641963.2023.2180019
Abstract: OBJECTIVES The present study aimed to investigate the effect and mechanism of angiotensin II-induced ferroptosis in vascular endothelial cells. METHODS In vitro, HUVECs were treated with AngII, AT1/2 R antagonist, P53 inhibitor, or their combinations.… read more here.
Keywords: angiotensin induced; endothelial cells; mda intracellular; p53 ... See more keywords
Upregulation of miR-140-5p uncouples mitochondria by targeting Bcl-xL in vascular smooth muscle cells in angiotensin II-induced hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2017696
Abstract: ABSTRACT Angiotensin II–induced vascular smooth muscle cell (VSMC) remodeling and dysfunction is a major contributor to the development of hypertension. In spite of the low content of mitochondria and their low contribution to bioenergetics in… read more here.
Keywords: angiotensin induced; mir 140; hypertension; uncouples mitochondria ... See more keywords
Roles of autophagy in angiotensin II‐induced cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13719
Abstract: Autophagy is a self‐degradation process of cytoplasmic components and occurs in the failing heart. Angiotensin II plays a critical role in the progression of heart failure and induces autophagy. We investigated the mechanism underlying angiotensin… read more here.
Keywords: angiotensin; angiotensin induced; apoptosis; autophagy angiotensin ... See more keywords
Effects of cholecalciferol and calcitriol on skeletal muscle proteolysis in angiotensin II-induced atrophy in differentiated C2C12 cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5726896
Abstract: Vitamin D3 has been proposed as a potential treatment to improve muscle atrophy in sarcopenic patients. Several lines of evidence suggested a possible crosslink between vitamin D and renin-angiotensin system contributing to skeletal muscle atrophy… read more here.
Keywords: angiotensin; angiotensin induced; muscle; physiology ... See more keywords
Protective role of short chain fatty acids against Angiotensin II-induced mitochondrial dysfunction in brain endothelial cells: Potential role of Heme Oxygenase 2
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735216
Abstract: Objectives: Short chain fatty acids (SCFAs), the main metabolites released from the gut microbiota, are reduced during hypertension. SCFAs play a beneficial role on the cardiovascular system. However, the effect of SCFAs on cerebrovascular endothelial… read more here.
Keywords: angiotensin induced; endothelial cells; role; brain ... See more keywords
Abstract 15127: Isorhamnetin Reverses Angiotensin Ii-induced Atrial Fibrillation Vulnerability Through Electrophysiological and Structural Reverse Remodeling in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.15127
Abstract: Background: Isorhamnetin (ISO), a natural flavonoid compound, has been shown to have strong antioxidant and antifibrotic effects in vivo and in vitro; however, no report has been shown on the effect of ISO on arrhythmic… read more here.
Keywords: vulnerability electrophysiological; structural reverse; angiotensin induced; electrophysiological structural ... See more keywords
Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats With Angiotensin II–Induced Hypertension
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hypertensionaha.120.15295
Abstract: Supplemental Digital Content is available in the text. The present study examined the extent to which leukocyte infiltration into the kidneys in Ang II (angiotensin II)-induced hypertension is determined by elevation of renal perfusion pressure… read more here.
Keywords: infiltration; hypertension; angiotensin induced; pressure ... See more keywords
Macrophage 12(S)-HETE Enhances Angiotensin II–Induced Contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries
Sign Up to like & getrecommendations! Published in 2021 at "Hypertension"
DOI: 10.1161/hypertensionaha.121.17824
Abstract: Supplemental Digital Content is available in the text. 12/15-LO (12/15-lipoxygenase), encoded by Alox15 gene, metabolizes arachidonic acid to 12(S)-HETE (12-hydroxyeicosatetraenoic acid). Macrophages are the major source of 12/15-LO among immune cells, and 12/15-LO plays a… read more here.
Keywords: macrophage hete; hypertension; receptor; angiotensin induced ... See more keywords