Risk of Mild Cognitive Impairment or Probable Dementia in New Users of Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.20680
Abstract: Key Points Question Is initiation of angiotensin II receptor blockers (ARBs), compared with angiotensin-converting enzyme inhibitors (ACEIs), associated with a reduced risk of cognitive impairment, after controlling for potential pretreatment confounders? Findings This active-comparator, new-user… read more here.
Keywords: new users; angiotensin receptor; cognitive impairment; receptor blockers ... See more keywords
Kidney Outcomes Following Angiotensin Receptor-Neprilysin Inhibitor vs Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy for Thrombotic Microangiopathy
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.32862
Abstract: Key Points Question Are there different kidney outcomes among patients diagnosed with malignant hypertension (mHTN)–associated thrombotic microangiopathy (TMA) who received sacubitril/valsartan compared with angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) therapy? Findings This cohort study with… read more here.
Keywords: inhibitor angiotensin; kidney; angiotensin receptor;
The use of angiotensin II receptor blocker is associated with greater recovery of cardiac function than angiotensin‐converting enzyme inhibitor in dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13790
Abstract: Angiotensin‐converting enzyme inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) have been shown to be associated with recovery of cardiac function in patients with dilated cardiomyopathy (DCM). The aim of this study was to assess… read more here.
Keywords: angiotensin converting; converting enzyme; cardiac function; recovery cardiac ... See more keywords
Angiotensin receptor‐neprilysin inhibitor in symptomatic patients with Duchenne dilated cardiomyopathy: A primetime
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13963
Abstract: Duchenne muscular dystrophy (DMD) is an X‐linked recessive neuromuscular disorder, characterized by significant long‐term cardiac involvement. Dilated cardiomyopathy (DCM) is the main cause of death in DMD, and angiotensin‐converting enzyme inhibitors (ACEi) and beta‐blockers (BB)… read more here.
Keywords: angiotensin; neprilysin inhibitor; receptor neprilysin; angiotensin receptor ... See more keywords
Effects of angiotensin receptor‐neprilysin inhibitor on insulin resistance in patients with heart failure
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14352
Abstract: Although the haemodynamic effects of angiotensin receptor‐neprilysin inhibitor (ARNI) on patients with heart failure have been demonstrated, the effect on glucose metabolism has not been fully elucidated. We retrospectively investigated the effect of ARNI on… read more here.
Keywords: heart failure; effects angiotensin; receptor neprilysin; heart ... See more keywords
Angiotensin‐converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin‐converting enzyme 2 in patients with cardiovascular disease
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2020
Abstract: Coronavirus disease 2019 (COVID‐19) is a widespread pandemic with an increased morbidity and mortality, especially for patients with cardiovascular diseases. Angiotensin‐converting enzyme 2 (ACE2) has been identified as necessary cell entry point for SARS‐CoV‐2. Previous… read more here.
Keywords: patients cardiovascular; converting enzyme; disease; angiotensin converting ... See more keywords
Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-κB-Mediated BDNF/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0450-5
Abstract: Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in… read more here.
Keywords: angiotensin receptor; expression; receptor blockers; memory impairment ... See more keywords
Angiotensin Receptor Blockers and the Risk of Suspected Drug-Induced Liver Injury: A Retrospective Cohort Study Using Electronic Health Record-Based Common Data Model in South Korea
Sign Up to like & getrecommendations! Published in 2024 at "Drug Safety"
DOI: 10.1007/s40264-024-01418-4
Abstract: Angiotensin receptor blockers are widely used antihypertensive drugs in South Korea. In 2021, the Korea Ministry of Food and Drug Safety acknowledged the need for national compensation for a drug-induced liver injury (DILI) after azilsartan… read more here.
Keywords: drug induced; receptor; receptor blockers; angiotensin receptor ... See more keywords
Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.10.010
Abstract: HighlightsC21 reduced weight loss and enhanced recovery in aged rats post‐stroke.C21 preserved non‐spatial and short‐term working memory in aged rats post‐stroke.C21 preserved reference memory and facilitated associative learning post‐stroke.C21 improved cognitive flexibility in aged rats… read more here.
Keywords: post stroke; stroke c21; aged animals; c21 ... See more keywords
Angiotensin II receptor type 1 - an update on structure, expression and pathology.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114673
Abstract: The AT1 receptor, a major effector of the renin-angiotensin system, has been extensively studied in the context of cardiovascular and renal disease. Moreover, angiotensin receptor blockers, sartans, are among the most frequently prescribed drugs for… read more here.
Keywords: pathology; angiotensin receptor; receptor type; structure ... See more keywords
Systematic review and meta-analysis of randomised controlled clinical trial evidence refutes relationship between pharmacotherapy with angiotensin-receptor blockers and an increased risk of cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of internal medicine"
DOI: 10.1016/j.ejim.2019.04.019
Abstract: AIMS The potential influence of angiotensin-receptor blockers (ARBs) on carcinogenesis is a much-debated topic. Both observational, as well as preclinical studies in rodent carcinogenic assays, suggest a major role of the Renin-Angiotensin-Aldosterone-System (RAAS) in cancer… read more here.
Keywords: randomised controlled; receptor blockers; angiotensin receptor; cancer ... See more keywords