The renin‐angiotensin system in COVID‐19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?
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DOI: 10.1002/bies.202000112
Abstract: This renin‐angiotensin system (RAS) interpretation is focused on differences in tissue dependence on RAS and on the topological hierarchy that allows mediators to act only on downstream tissues. read more here.
Keywords: ace2 targeting; renin angiotensin; system covid; covid ace2 ... See more keywords
Renin‐angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells
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DOI: 10.1002/stem.3339
Abstract: Angiotensin‐converting enzyme (ACE), a key element of the renin‐angiotensin system (RAS), has recently been identified as a new marker of both adult and embryonic human hematopoietic stem/progenitor cells (HSPCs). However, whether a full renin‐angiotensin pathway… read more here.
Keywords: renin angiotensin; stem progenitor; hematopoietic stem; angiotensin ... See more keywords
Bi-allelic mutations in renin-angiotensin system genes, associated with renal tubular dysgenesis, can also present as a progressive chronic kidney disease
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DOI: 10.1007/s00467-020-04524-4
Abstract: Background Bi-allelic loss of function variations in genes encoding proteins of the renin-angiotensin system ( AGT , ACE , REN , AGTR1 ) are associated with autosomal recessive renal tubular dysgenesis, a severe disease characterized… read more here.
Keywords: tubular dysgenesis; disease; renin angiotensin; renal tubular ... See more keywords
Chronological renal resistive index increases related to atherosclerotic factors, and effect of renin-angiotensin system inhibitors
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DOI: 10.1007/s10157-018-1667-y
Abstract: BackgroundRenal resistive index (RI) calculated using renal Doppler ultrasonography (RDU) has recently been considered a clinically important indicator of renal outcome, survival, and systemic arteriosclerotic disorders. However, the cause of RI elevation remains unclear. The… read more here.
Keywords: resistive index; renin angiotensin; effect renin; elevation ... See more keywords
Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications
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DOI: 10.1007/s10741-020-10022-4
Abstract: Coronavirus disease 2019 (COVID-19) is due to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 which binds and enters the host cells through the angiotensin-converting enzyme (ACE)2. While the potential for benefit with the use of renin-angiotensin-aldosterone… read more here.
Keywords: disease; evidence; renin angiotensin; angiotensin ... See more keywords
Vaccines against components of the renin–angiotensin system
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DOI: 10.1007/s10741-020-10033-1
Abstract: Even though effective drugs for treating hypertension are available, a great percentage of patients have inadequate control of their blood pressure. Unwanted side effects and inappropriate oral drug adherence are important factors that contribute to… read more here.
Keywords: renin angiotensin; vaccines components; components renin; angiotensin ... See more keywords
Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease
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DOI: 10.1007/s11481-019-09894-7
Abstract: The renin angiotensin system (RAS), which is classically known for blood pressure regulation, has functions beyond this. There are two axes of RAS that work to counterbalance each other and are active throughout the body,… read more here.
Keywords: protective arm; renin angiotensin; angiotensin system; angiotensin ... See more keywords
Renin-angiotensin system inhibition in COVID-19 patients
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DOI: 10.1007/s12471-020-01439-5
Abstract: Angiotensin-converting enzyme (ACE) inhibitors (ACEIs) and angiotensin II type‑1 receptor blockers (ARBs) are among the most widely prescribed drugs for the treatment of arterial hypertension, heart failure and chronic kidney disease. A number of studies, mainly in… read more here.
Keywords: covid patients; renin angiotensin; aceis arbs; covid ... See more keywords
Obesity and aging affects skeletal muscle renin–angiotensin system and myosin heavy chain proportions in pre-diabetic Zucker rats
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DOI: 10.1007/s13105-019-00689-1
Abstract: There is a gap in the knowledge regarding regulation of local renin–angiotensin system (RAS) in skeletal muscle during development of obesity and insulin resistance in vivo. This study evaluates the obesity- and age-related changes in… read more here.
Keywords: skeletal muscle; muscle; renin angiotensin; obesity ... See more keywords
Effect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial
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DOI: 10.1007/s40620-020-00944-5
Abstract: Acidosis-induced kidney injury is mediated by the intrarenal renin-angiotensin system, for which urinary renin is a potential marker. Therefore, we hypothesized that sodium bicarbonate supplementation reduces urinary renin excretion in patients with chronic kidney disease… read more here.
Keywords: renin; renin angiotensin; bicarbonate; angiotensin system ... See more keywords
Renin-angiotensin system inhibitors effect before and during hospitalization in COVID-19 outcomes: Final analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID-19) registry
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DOI: 10.1016/j.ahj.2021.04.001
Abstract: BACKGROUND The use of Renin-Angiotensin system inhibitors (RASi) in patients with coronavirus disease 2019 (COVID-19) has been questioned because both share a target receptor site. METHODS HOPE-COVID-19 (NCT04334291) is an international investigator-initiated registry. Patients are… read more here.
Keywords: hope covid; covid; renin angiotensin; angiotensin system ... See more keywords