ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer
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DOI: 10.1158/0008-5472.can-19-4028
Abstract: These findings identify amplified ERK1/2 signaling in KRAS-mutated colorectal cancer cells as a driver of tumor–stroma interactions that favor formation of metastases in the liver. Carcinoma development in colorectal cancer is driven by genetic alterations… read more here.
Keywords: metastasis; cancer cells; cancer; angpt2 cxcr4 ... See more keywords