Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
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DOI: 10.1016/j.jlr.2021.100112
Abstract: High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3… read more here.
Keywords: angptl3; inhibition; endothelial lipase; hdl ... See more keywords
Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3
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DOI: 10.1080/21655979.2021.2024951
Abstract: ABSTRACT Angiopoietin-like 3 (ANGPTL3) has been uncovered to play an oncogenic role in several kinds of human malignancies. Nevertheless, whether ANGPTL3 functions in cervical cancer (CC) has not yet been reported. This paper is intended… read more here.
Keywords: proliferation migration; cell proliferation; proliferation; angptl3 ... See more keywords
Abstract Or121: Functional dissection of ANGPTL3
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DOI: 10.1161/atv.45.suppl_1.or121
Abstract: Dyslipidemia is a risk factor for metabolic diseases, emphasizing the importance of regulating lipoprotein metabolism. Levels of lipoproteins are regulated, in part, by extracellular lipases including lipoprotein lipase (LPL) and endothelial lipase (EL). Angiopoietin-like-3 (ANGPTL3)… read more here.
Keywords: angptl8; residues angptl3; inhibition; lipase ... See more keywords
Abstract 4365973: Circulating Angiopoietin-Like Protein 3 in Response to Statin Therapy in Acute Coronary Syndrome and Stable Coronary Artery Disease
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DOI: 10.1161/circ.152.suppl_3.4365973
Abstract: Background: Anti-atherosclerotic response to statin has been shown to differ in patients with ACS and stable CAD. Statin induced a greater reduction of subsequent cardiac events’ risks and more plaque regression in ACS patients. This… read more here.
Keywords: statin therapy; stable cad; statin; angptl3 ... See more keywords
Angiopoietin-like 3 monomers are abundant in human plasma but are unable to inhibit endothelial lipase.
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DOI: 10.1172/jci.insight.197827
Abstract: Angiopoietin-like 3 (ANGPTL3) is a major regulator of lipoprotein metabolism. ANGPTL3 deficiency results in lower levels of triglycerides, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C), and may protect from cardiovascular disease. ANGPTL3 oligomerizes with ANGPTL8 to inhibit… read more here.
Keywords: angiopoietin like; human plasma; lipase; angptl3 ... See more keywords
ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome
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DOI: 10.1186/s12944-022-01632-y
Abstract: Background It is unclear why primary nephrotic syndrome (PNS) patients often have dyslipidemia. Recent studies have shown that angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipid metabolism. In this study, we explored how… read more here.
Keywords: mice; angptl3 mice; primary nephrotic; pns ... See more keywords
Inhibition of Angiopoietin-Like 3 (ANGPTL3) Reduces Adipose Tissue Insulin Resistance in Patients With Familial Partial Lipodystrophy
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DOI: 10.1210/jendso/bvab048.100
Abstract: Abstract Familial partial lipodystrophy (FPLD) is a rare disease characterized by selective loss of peripheral subcutaneous fat, usually affecting the trunk and limbs, but preservation in other areas, such as the face and neck. It… read more here.
Keywords: patients fpld; tissue insulin; angptl3; familial partial ... See more keywords
In Silico Description of the Direct Inhibition Mechanism of Endothelial Lipase by ANGPTL3
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DOI: 10.3390/ijms25063555
Abstract: Angiopoietin-like protein 3 (ANGPTL3) is a plasmatic protein that plays a crucial role in lipoprotein metabolism by inhibiting the lipoprotein lipase (LPL) and the endothelial lipase (EL) responsible for the hydrolysis of phospholipids on high-density… read more here.
Keywords: description direct; endothelial lipase; lipase; mechanism ... See more keywords
Gene Silencing of Angiopoietin-like 3 (ANGPTL3) Induced De Novo Lipogenesis and Lipid Accumulation in Huh7 Cell Line
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DOI: 10.3390/ijms25073708
Abstract: Angiopoietin-like 3 (ANGPTL3) is a hepatokine acting as a negative regulator of lipoprotein lipase (LPL). Vupanorsen, an ANGPTL3 directed antisense oligonucleotide, showed an unexpected increase in liver fat content in humans. Here, we investigated the… read more here.
Keywords: angiopoietin like; huh7; novo lipogenesis; accumulation ... See more keywords
Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
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DOI: 10.3390/metabo12060539
Abstract: Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains… read more here.
Keywords: angptl8; menopausal status; triglyceride elevation; angptl3 ... See more keywords