Discovery, Optimization, and Evaluation of Novel ANGPTL3 Modulators for the Treatment of Hyperlipidemia.
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DOI: 10.1021/acs.jmedchem.5c00732
Abstract: Angiopoietin-like protein 3 (ANGPTL3) has emerged as an attractive therapeutic target for treating hyperlipidemia. Evinacumab, a monoclonal antibody targeting ANGPTL3, was approved by the FDA for homozygous familial hypercholesterolemia in 2021. Here, a series of… read more here.
Keywords: optimization evaluation; angptl3 modulators; discovery optimization; novel angptl3 ... See more keywords