Research Progress on the Involvement of ANGPTL4 and Loss-of-Function Variants in Lipid Metabolism and Coronary Heart Disease: Is the “Prime Time” of ANGPTL4-Targeted Therapy for Coronary Heart Disease Approaching?
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07001-0
Abstract: Background Multiple genetic studies have confirmed the definitive link among the loss-of-function variants of angiogenin-like protein 4 (ANGPTL4), significantly decreased plasma triglyceride (TG) levels, and reduced risk of coronary heart disease (CHD). The potential therapeutic… read more here.
Keywords: heart; angptl4; heart disease; coronary heart ... See more keywords
Circulating and tissue specific transcription of angiopoietin-like protein 4 in human Type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154192
Abstract: AIMS Obesity is associated with adipose tissue (AT) dysfunction marked by cellular hypertrophy, inflammation, hypoxia and fibrosis. Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase which regulates triglyceride storage. Recently, inhibition of ANGPTL4 has been suggested… read more here.
Keywords: protein; angptl4; like protein; tissue ... See more keywords
Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.06.018
Abstract: Objective Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels. Systemic ANGPTL4 increases during prolonged fasting and is suggested to be secreted from… read more here.
Keywords: protein; glucagon; camp; angptl4 ... See more keywords
ANGPTL4 negatively regulates the progression of osteosarcoma by remodeling branched-chain amino acid metabolism
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DOI: 10.1038/s41420-022-01029-x
Abstract: Angiopoietin-like-4 (ANGPTL4), a secreted glycoprotein that is mainly known as a regulator in lipid metabolism, now, is also indicated to be involved in the regulation of cancer progression and metastasis. However, little is known about… read more here.
Keywords: progression; branched chain; angptl4; amino ... See more keywords
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214081120
Abstract: Triglyceride (TG) metabolism is highly regulated by angiopoietin-like protein (ANGPTL) family members [Y. Q. Chen et al., J. Lipid Res. 61, 1203-1220 (2020)]. During feeding, ANGPTL8 forms complexes with the fibrinogen-like domain-containing protein ANGPTL4 in adipose tissue… read more here.
Keywords: lpl activity; plasminogen; angptl4; plasmin ... See more keywords
ANGPTL4: A Predictive Marker for Diabetic Nephropathy
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DOI: 10.1155/2019/4943191
Abstract: Background ANGPTL4 is a glycoprotein that is involved in regulating triglyceride metabolism by inhibiting LPL activity under fasting conditions. Additionally, ANGPTL4 has been suggested as a link between hypertriglyceridemia and albuminuria in the nephrotic syndrome.… read more here.
Keywords: circulating angptl4; angptl4; igfbp1 igfbp4; diabetic nephropathy ... See more keywords
Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1135827
Abstract: Osteoarthritis (OA) is a frequently observed condition in aged people. OA cartilage is characterized by chondrocyte apoptosis, chondrocyte inflammation, and hyperactive catabolism of extracellular matrix. However, the specific molecular mechanisms remain unclear. Recent data has… read more here.
Keywords: inflammation; extracellular matrix; apoptosis; osteoarthritis ... See more keywords
Aqueous Level of ANGPTL4 Correlates with the OCTA Metrics of Diabetic Macular Edema in NPDR
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/8435603
Abstract: Purpose To investigate the aqueous levels of angiogenic factors in nonproliferative diabetic retinopathy (NPDR) patients with diabetic macular edema (DME) and to ascertain their association with optical coherence tomography angiography (OCTA) metrics. Methods This study… read more here.
Keywords: angptl4; npdr dme; dme; dme group ... See more keywords
Angiopoietin-like 4 is a critical regulator of fibroblasts during pulmonary fibrosis development.
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DOI: 10.1165/rcmb.2022-0304oc
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial pneumonia caused by the excessive production and deposition of extracellular matrix components, including type I collagen. Activated fibroblasts, called α-smooth muscle actin (α-SMA)-expressing myofibroblasts,… read more here.
Keywords: pulmonary fibrosis; like critical; angiopoietin like; angptl4 ... See more keywords
Angiopoietin-like-4 and minimal change disease
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DOI: 10.1371/journal.pone.0176198
Abstract: Background Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the… read more here.
Keywords: change disease; angptl4; disease; mcd ... See more keywords
ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis
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DOI: 10.18632/oncotarget.19018
Abstract: In an ongoing effort to identify molecular determinants regulating melanoma brain metastasis, we previously identified Angiopoietin-like 4 (ANGPTL4) as a component of the molecular signature of such metastases. The aim of this study was to… read more here.
Keywords: melanoma; angptl4; cutaneous melanoma; brain metastasis ... See more keywords