Asymmetric Total Syntheses of (-)-Angustureine and (-)-Cuspareine via Rhodium-Catalyzed Hydroamination.
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DOI: 10.1021/acs.orglett.9b04334
Abstract: Concise syntheses of the Hancock alkaloids (-)-angustureine and (-)-cuspareine are presented, applying and refining a recently developed rhodium-catalyzed hydroamination for the stereoselective construction of the chiral secondary amine. Furthermore, the syntheses include an allene synthesis… read more here.
Keywords: rhodium catalyzed; catalyzed hydroamination; angustureine cuspareine;