Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800200
Abstract: A series of substituteed pyrazol‐4‐yl‐diazene derivatives were found to be effective inhibitors against α‐glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with Ki values in the… read more here.
Keywords: carbonic anhydrase; glycosidase; derivatives potent; pyrazoles derivatives ... See more keywords
QSAR and docking studies on Triazole Benzene Sulfonamides with human Carbonic anhydrase IX inhibitory activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Chemometrics"
DOI: 10.1002/cem.3189
Abstract: Cancer is the second leading cause of death worldwide, and breast cancer accounts for 2.09 million cases in the year 2018. Hypoxia‐related human carbonic anhydrase IX enzyme was found to play a key role in… read more here.
Keywords: carbonic anhydrase; anhydrase inhibitory; triazole benzene; human carbonic ... See more keywords
Enhanced sequestration of carbon dioxide into calcium carbonate using pressure and a carbonic anhydrase from alkaliphilic Coleofasciculus chthonoplastes
Sign Up to like & getrecommendations! Published in 2021 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202100033
Abstract: CO2 in the atmosphere is a major contributor to global warming but at the same time it has the potential to be a carbon source for advanced biomanufacturing. To utilize CO2, carbonic anhydrase has been… read more here.
Keywords: anhydrase alkaliphilic; pressure; anhydrase; carbonic anhydrase ... See more keywords
Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and α‐glycosidase enzymes inhibitors: The novel N,N′‐bis‐cyanomethylamine and alkoxymethylamine derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22042
Abstract: During this investigation, N,N′‐bis‐azidomethylamines, N,N′‐bis‐cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, functional properties were investigated, and anticholinergic and antidiabetic properties of those compounds… read more here.
Keywords: carbonic anhydrase; novel bis; bis cyanomethylamine; alkoxymethylamine derivatives ... See more keywords
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Research Reviews"
DOI: 10.1002/med.21497
Abstract: Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely present in normal tissues, but highly overexpressed in a large number of solid tumors, where it actively contributes to survival and metastatic… read more here.
Keywords: carbonic anhydrase; anhydrase targets; inhibition carbonic; cancer ... See more keywords
The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10015-w
Abstract: Carbonic anhydrase catalyses the interconversion of carbon dioxide and water to bicarbonate and protons. It was unknown if the industrial-relevant acetogen Clostridium autoethanogenum possesses these enzymes. We identified two putative carbonic anhydrase genes in its… read more here.
Keywords: class; carbonic anhydrase; clostridium autoethanogenum; anhydrase ... See more keywords
Unfolding intermediates of the mutant His-107-Tyr of human carbonic anhydrase II
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-017-1279-1
Abstract: The mutant His-107-Tyr of human carbonic anhydrase II (HCA II) is highly unstable and has long been linked to a misfolding disease known as carbonic anhydrase deficiency syndrome (CADS). High temperature unfolding trajectories of the… read more here.
Keywords: carbonic anhydrase; human carbonic; mutant 107; 107 tyr ... See more keywords
Induction of calcite precipitation through heightened production of extracellular carbonic anhydrase by CO2 sequestering bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2018.01.081
Abstract: The thermo-alkalotolerant bacterium exhibiting heightened extracellular carbonic anhydrase (CA) activity, survived at 100 mM sodium bicarbonateand 5% gaseous CO2 was identified as Bacillus sp. by 16S rRNA sequencing. Extracellular carbonic anhydrase was purified by ammonium sulfate… read more here.
Keywords: carbonic anhydrase; production; extracellular carbonic; precipitation ... See more keywords
Seasonal variations of carbonic anhydrase activity in Chongqing urban section of Jialing River and its influencing factors.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.03.097
Abstract: Carbonic anhydrase (CA) is an enzyme in algal carbon-utilization that plays an important role in the formation of algal blooms. A year-long monitoring program in the shore area of Chongqing Urban Section of the Jialing… read more here.
Keywords: urban section; carbonic anhydrase; section jialing; river ... See more keywords
Quantum mechanical study of human carbonic anhydrase II in complex with polyamines as novel inhibitors: Kinetic and thermodynamic investigation
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2020.112911
Abstract: Abstract Spermine and spermidine polyamines are investigated as a new class inhibitors of different carbonic anhydrase (CA) isoforms using DFT calculations. Our results indicate these two polyamines, inhibited the human carbonic anhydrase with very different… read more here.
Keywords: carbonic anhydrase; human carbonic; study human; quantum mechanical ... See more keywords
Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.034
Abstract: In the quest for novel effective carbonic anhydrase inhibitors, some sulfonamide derivatives of pyridyl-indole based chalcone were synthesized and screened in vitro for inhibitory activity against human carbonic anhydrase IX isoform. Among all the synthesized compounds… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; sulfonamide derivatives; pyridyl indole ... See more keywords