Some phenolic natural compounds as carbonic anhydrase inhibitors: An in vitro and in silico study
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100476
Abstract: This paper presents experimental and molecular docking studies on the inhibitory effects of tyrosol, hydroxytyrosol, luteolin, diosmetin, caffeic acid, luteolin 7‐O‐glycoside, and apigenin 7‐O‐glycoside from olive (Olea europaea L.) leaf against human carbonic anhydrase (hCA,… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; natural compounds; compounds carbonic ... See more keywords
Synthesis, characterization and biological evaluation of tertiary sulfonamide derivatives of pyridyl-indole based heteroaryl chalcone as potential carbonic anhydrase IX inhibitors and anticancer agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.05.034
Abstract: In the quest for novel effective carbonic anhydrase inhibitors, some sulfonamide derivatives of pyridyl-indole based chalcone were synthesized and screened in vitro for inhibitory activity against human carbonic anhydrase IX isoform. Among all the synthesized compounds… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; sulfonamide derivatives; pyridyl indole ... See more keywords
Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.019
Abstract: We report the design, synthesis and pharmacological assessment of novel benzenesulfonamide derivatives acting as effective carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. All the synthesized compounds were screened for their CA inhibitory action against four isoforms… read more here.
Keywords: design synthesis; anhydrase inhibitors; carbonic anhydrase; hca ... See more keywords
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112923
Abstract: Carbonic anhydrase (CA, EC 4.2.1.1) is an enzyme and a very omnipresent zinc metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide and bicarbonate; a reaction which plays a crucial role in many… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; medicinal chemistry; chemistry ... See more keywords
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01607
Abstract: We report the synthesis of a series of hybrid compounds incorporating 6- and 7-substituted coumarins (carbonic anhydrase, CA inhibitors) derivatized with clinically used NSAIDs (indomethacin, sulindac, ketoprofen, ibuprofen, diclofenac, ketorolac, etc., cyclooxygenase inhibitors) as agents… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; synthesis; rheumatoid arthritis ... See more keywords
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.
Sign Up to like & getrecommendations! Published in 2017 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00399
Abstract: Incorporation of the purine/pyrimidine moieties as tails to classical benzenesulfonamide scaffolds afforded two series of human (h) carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The compounds were designed according to the molecular hybridization approach, in order… read more here.
Keywords: new sulfonamide; anhydrase inhibitors; carbonic anhydrase; hca ... See more keywords
Bis-benzoxaboroles: Design, Synthesis, and Biological Evaluation as Carbonic Anhydrase Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00252
Abstract: The synthesis, characterization, and biological evaluation of a series of compounds incorporating two or three benzoxaborole moieties is reported. Three different synthetic strategies were used to explore within this series as much chemical space as… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; biological evaluation; synthesis ... See more keywords
Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2019.1709632
Abstract: Abstract Carbonic anhydrase (CA) inhibitors have a long history of safe clinical use as mild diuretics, in the treatment of glaucoma and for altitude sickness prevention. In this study, we aimed to determine if CA… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; platelet procoagulant; thrombosis ... See more keywords
Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008–2018)
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1508453
Abstract: ABSTRACT Introduction: Human carbonic anhydrases (CA, EC 4.2.1.1) IX and XII are tumor-associated proteins, being part of the molecular machinery that tumor cells build as adaptive responses to hypoxia and acidic conditions characteristic of the… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; antitumor antimetastatic; inhibitors antitumor ... See more keywords
Paradoxical response to carbonic anhydrase inhibitors in patients with intraretinal cystoid spaces
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2019.1622021
Abstract: ABSTRACT Background: Intraretinal cystoid spaces (IRCS) are fluid-filled spaces seen in some retinal dystrophies and often treated with carbonic anhydrase inhibitors. The purpose of this study is to report an unexpected bilateral improvement in the… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; intraretinal cystoid; cystoid spaces ... See more keywords
Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1722121
Abstract: Abstract Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficiently inhibited by compounds 2–13 with inhibition… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; human carbonic; mercaptoquinazolin one ... See more keywords