New 7âhydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400482
Abstract: Carbonic anhydrases (CAs) are crucial in regulating various physiological processes in the body. The overexpression of isoforms human carbonic anhydrases (hCA) IX and hCA XII is linked to tumour progression. The selective inhibition of CA… read more here.
Keywords: hca xii; carbonic anhydrase; xii; human carbonic ... See more keywords
Carbonic anhydrase XII as biomarker and therapeutic target in ovarian carcinomas
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DOI: 10.1371/journal.pone.0271630
Abstract: Targeting the tumor-associated carbonic anhydrase XII (CA XII) is considered a promising strategy to improve cancer treatment. As such progress is highly demanded for ovarian carcinomas, the present study aimed to provide deeper information about… read more here.
Keywords: anhydrase xii; ovarian carcinomas; xii; carbonic anhydrase ... See more keywords
Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold
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DOI: 10.3390/molecules29143290
Abstract: A new series of piperazine derivatives were synthesized and studied with the aim of obtaining dual inhibitors of P-glycoprotein (P-gp) and carbonic anhydrase XII (hCA XII) to synergistically overcome the P-gp-mediated multidrug resistance (MDR) in… read more here.
Keywords: hca xii; carbonic anhydrase; dual inhibitors; xii ... See more keywords