Chiral Aniline Synthesis via Stereospecific C(sp3)–C(sp2) Coupling of Boronic Esters with Aryl Hydrazines
Sign Up to like & getrecommendations! Published in 2018 at "Organic Letters"
DOI: 10.1021/acs.orglett.8b02615
Abstract: An enantiospecific coupling between alkylboronic esters and lithiated aryl hydrazines is described. The reaction proceeds under transition-metal-free conditions and is promoted by acylation of a hydrazinyl arylboronate complex, which triggers a N–N bond cleavage with… read more here.
Keywords: via stereospecific; chiral aniline; aryl hydrazines; synthesis ... See more keywords
A photochemical dehydrogenative strategy for aniline synthesis
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2539-7
Abstract: Chemical reactions that reliably join two molecular fragments together (cross-couplings) are essential to the discovery and manufacture of pharmaceuticals and agrochemicals1,2. The introduction of amines onto functionalized aromatics at specific and pre-determined positions (ortho versus… read more here.
Keywords: strategy aniline; chemistry; photochemical dehydrogenative; aniline synthesis ... See more keywords