Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.
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DOI: 10.1016/j.ejmech.2017.07.040
Abstract: A series of novel 4-anilinoquinoline derivatives were synthesized and evaluated for their antiproliferative activities. Among them, 14h exhibited the most potent cytotoxic activity with IC50 values ranging from 1.5 to 3.9 nM against all tested cancer… read more here.
Keywords: tubulin depolymerization; anilinoquinoline derivatives; evaluation; design synthesis ... See more keywords