Establishing a health-based recommended occupational exposure limit for nitrous oxide using experimental animal data - A systematic review protocol.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.108711
Abstract: Nitrous oxide (N2O) is widely used as inhalation analgesic and anaesthetic in medical, paramedical, and veterinary practice. Previous evaluations resulted in classification of N2O as a possible risk factor for adverse reproductive health outcomes based… read more here.
Keywords: nitrous oxide; systematic review; exposure; review ... See more keywords
Translation from animal to clinical studies, choosing the optimal moment
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DOI: 10.1038/s41390-020-0820-y
Abstract: We want to thank Davidson et al. for their comments and thoughts as reflected in their commentary, “When is a potential new neuroprotective treatment ready for translation?”, on our publication concerning 2-iminobiotin following perinatal asphyxia.… read more here.
Keywords: clinical studies; animal clinical; translation animal; translation ... See more keywords
A robust Bayesian meta-analytic approach to incorporate animal data into phase I oncology trials
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DOI: 10.1177/0962280218820040
Abstract: Before a first-in-man trial is conducted, preclinical studies are performed in animals to help characterise the safety profile of the new medicine. We propose a robust Bayesian hierarchical model to synthesise animal and human toxicity… read more here.
Keywords: phase; robust bayesian; animal species; toxicity ... See more keywords