Can Quality Improvement Tools Overcome the Translational Roadblock—the Vital Influence of the Researcher
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0524-8
Abstract: Both special issues BChallenges and Controversies in Translational Stroke Research, Part 1 and 2^ provide an excellent overview of the methodological challenges encountered in the various stages of planning, implementation, and evaluation of preclinical stroke… read more here.
Keywords: improvement; quality; research; stroke research ... See more keywords
Replacement techniques to reduce animal experiments in drug and nanoparticle development
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-020-00487-8
Abstract: Background Animals have been used for the testing of new drugs and nanoparticles to determine their safety and effectiveness before application in humans. Numerous drugs and nanoparticles have been developed through animal tests, and development… read more here.
Keywords: replacement techniques; drugs nanoparticles; techniques reduce; animal experiments ... See more keywords
Experiments done in Black-6 mice: what does it mean?
Sign Up to like & getrecommendations! Published in 2019 at "Lab Animal"
DOI: 10.1038/s41684-019-0288-8
Abstract: Low replicability of animal experiments is perceived as a major hurdle in the field of biomedicine. Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to… read more here.
Keywords: c57bl c57bl; c57bl mice; experiments done; mice ... See more keywords
In vitro cellular model systems provide a promising alternative to animal experiments for studying the intestine-organ axis
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2025.2452620
Abstract: Abstract Limiting animal experiments is essential for ethical issues and also because scientific evidence highlights the discrepancies between human and animal metabolism. This review aims to provide a critical discussion of the strengths and limitations… read more here.
Keywords: model systems; animal experiments; vitro cellular; culture ... See more keywords
Difference of auditory brainstem responses by stimulating to round and oval window in animal experiments
Sign Up to like & getrecommendations! Published in 2017 at "Bioengineered"
DOI: 10.1080/21655979.2016.1226662
Abstract: ABSTACT To ensure the safety and efficacy of implantable hearing aids, animal experiments are an essential developmental procedure, in particular, auditory brainstem responses (ABRs) can be used to verify the objective effectiveness of implantable hearing… read more here.
Keywords: window; auditory brainstem; round; animal experiments ... See more keywords
Sharing of data archive of radiation exposure animal experiments in QST/NIRS and IES.
Sign Up to like & getrecommendations! Published in 2024 at "Radiation protection dosimetry"
DOI: 10.1093/rpd/ncae122
Abstract: Institute for Radiological Science (NIRS), National Institutes for Quantum Science and Technology (QST), and Institute for Environmental Sciences (IES) have conducted large-scale animal experiments for radiation risk analyses in terms of life shortening and cancer… read more here.
Keywords: animal experiments; radiation; data archive; sharing data ... See more keywords
The risk of bias of animal experiments in implant dentistry: a methodological study
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Oral Implants Research"
DOI: 10.1111/clr.12852
Abstract: OBJECTIVES To evaluate the risk of bias (ROB) in reports of randomised controlled trials (RCTs) of animal experiments published in implant dentistry, and to explore the association between animal experiment characteristics and ROB. MATERIAL AND… read more here.
Keywords: implant dentistry; experiments implant; rob; animal experiments ... See more keywords
Hypoxia: Animal experiments and clinical implications
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.13429
Abstract: The developing fetus has some unique physiological properties that differ from properties in extra‐uterine life. The fetus exists in a hypoxemic condition as a result of the presence of the placenta, which serves as a… read more here.
Keywords: fetus; experiments clinical; clinical implications; physiology ... See more keywords
Animal experiments in biomedical research: Knowledge, self-evaluation and attitudes of biology and medical students.
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory animals"
DOI: 10.1177/00236772221080833
Abstract: Animal experiments in biomedical research are debated in public, within the scientific community and among students. Despite increased efforts to reduce, refine and replace animal experiments, they remain integral components of the job of a… read more here.
Keywords: self evaluation; animal experiments; knowledge self; biomedical research ... See more keywords
Experiences of early career researchers: Influences on the design and reporting of animal experiments, and the practical and emotional support needed to enhance best practice methods
Sign Up to like & getrecommendations! Published in 2024 at "Laboratory Animals"
DOI: 10.1177/00236772241242850
Abstract: While best practice methodology in animal research aims to address reproducibility and translational issues, awareness and implementation remains low. Preclinical systematic reviews have highlighted many flaws, including issues with internal validity and reporting. With early… read more here.
Keywords: career researchers; animal experiments; early career; best practice ... See more keywords
Heterogeneity of animal experiments and how to deal with it
Sign Up to like & getrecommendations! Published in 2024 at "Laboratory Animals"
DOI: 10.1177/00236772241260173
Abstract: Heterogeneity of study samples is ubiquitous in animal experiments. Here, we discuss the different options of how to deal with heterogeneity in the statistical analysis of a single experiment. Specifically, data from different sub-groups (e.g.… read more here.
Keywords: heterogenization factors; deal heterogeneity; animal experiments; heterogenization ... See more keywords