Can Quality Improvement Tools Overcome the Translational Roadblock—the Vital Influence of the Researcher
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0524-8
Abstract: Both special issues BChallenges and Controversies in Translational Stroke Research, Part 1 and 2^ provide an excellent overview of the methodological challenges encountered in the various stages of planning, implementation, and evaluation of preclinical stroke… read more here.
Keywords: improvement; quality; research; stroke research ... See more keywords
Replacement techniques to reduce animal experiments in drug and nanoparticle development
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-020-00487-8
Abstract: Background Animals have been used for the testing of new drugs and nanoparticles to determine their safety and effectiveness before application in humans. Numerous drugs and nanoparticles have been developed through animal tests, and development… read more here.
Keywords: replacement techniques; drugs nanoparticles; techniques reduce; animal experiments ... See more keywords
Experiments done in Black-6 mice: what does it mean?
Sign Up to like & getrecommendations! Published in 2019 at "Lab Animal"
DOI: 10.1038/s41684-019-0288-8
Abstract: Low replicability of animal experiments is perceived as a major hurdle in the field of biomedicine. Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to… read more here.
Keywords: c57bl c57bl; c57bl mice; experiments done; mice ... See more keywords
Difference of auditory brainstem responses by stimulating to round and oval window in animal experiments
Sign Up to like & getrecommendations! Published in 2017 at "Bioengineered"
DOI: 10.1080/21655979.2016.1226662
Abstract: ABSTACT To ensure the safety and efficacy of implantable hearing aids, animal experiments are an essential developmental procedure, in particular, auditory brainstem responses (ABRs) can be used to verify the objective effectiveness of implantable hearing… read more here.
Keywords: window; auditory brainstem; round; animal experiments ... See more keywords
The risk of bias of animal experiments in implant dentistry: a methodological study
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Oral Implants Research"
DOI: 10.1111/clr.12852
Abstract: OBJECTIVES To evaluate the risk of bias (ROB) in reports of randomised controlled trials (RCTs) of animal experiments published in implant dentistry, and to explore the association between animal experiment characteristics and ROB. MATERIAL AND… read more here.
Keywords: implant dentistry; experiments implant; rob; animal experiments ... See more keywords
Hypoxia: Animal experiments and clinical implications
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.13429
Abstract: The developing fetus has some unique physiological properties that differ from properties in extra‐uterine life. The fetus exists in a hypoxemic condition as a result of the presence of the placenta, which serves as a… read more here.
Keywords: fetus; experiments clinical; clinical implications; physiology ... See more keywords
Animal experiments in biomedical research: Knowledge, self-evaluation and attitudes of biology and medical students.
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory animals"
DOI: 10.1177/00236772221080833
Abstract: Animal experiments in biomedical research are debated in public, within the scientific community and among students. Despite increased efforts to reduce, refine and replace animal experiments, they remain integral components of the job of a… read more here.
Keywords: self evaluation; animal experiments; knowledge self; biomedical research ... See more keywords
High-throughput Genetically Modified Animal Experiments Achieved by Next-generation Mammalian Genetics
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biological Rhythms"
DOI: 10.1177/07487304221075002
Abstract: Animal models are essential tools for modern scientists to conduct biological experiments and investigate their hypotheses in vivo. However, for the past decade, raising the throughput of such animal experiments has been a great challenge.… read more here.
Keywords: generation; high throughput; next generation; animal experiments ... See more keywords