New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin
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DOI: 10.1002/med.21494
Abstract: Polymyxin B and colistin (polymyxin E) are bactericidal pentacationic lipopeptides that act specifically on Gram‐negative bacteria, first by disrupting their outermost permeability barrier, the outer membrane (OM), and then damaging the cytoplasmic membrane. The discovery… read more here.
Keywords: animal infection; infection; polymyxin; infection models ... See more keywords