Establishment of an animal model of immune‐related adverse events induced by immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70011
Abstract: Immunotherapy, specifically immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment. However, it can also cause immune‐related adverse events (irAEs). This study aimed to develop a clinically practical animal model of irAEs using BALB/c mice. read more here.
Keywords: adverse events; related adverse; immune checkpoint; immune related ... See more keywords
Study of retinal neurodegeneration and maculopathy in diabetic Meriones shawi: A particular animal model with human‐like macula
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24245
Abstract: The purpose of this work was to evaluate a potentially useful animal model, Meriones shawi (M.sh)—developing metabolic X syndrome, diabetes and possessing a visual streak similar to human macula—in the study of diabetic retinopathy and… read more here.
Keywords: model; meriones shawi; macula study; animal model ... See more keywords
A novel pilot animal model for bone augmentation using osseous shell technique for preclinical in vivo studies
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dental Research"
DOI: 10.1002/cre2.644
Abstract: Bone grafting is commonly used to reconstruct skeletal defects in the craniofacial region. Several bone augmentation models have been developed to evaluate bone formation using novel bone substitute materials. The aim of this study was… read more here.
Keywords: bone; animal model; augmentation using; bone augmentation ... See more keywords
The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23556
Abstract: The role of astrocytes in the pathophysiology of multiple sclerosis (MS) is discussed controversially. Especially the formation of the glial scar is often believed to act as a barrier for remyelination. At the same time,… read more here.
Keywords: remyelination; glial scar; multiple sclerosis; animal model ... See more keywords
Ascorbic acid supplementation attenuates schizophrenia‐like symptoms in an animal model induced by ketamine
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10058
Abstract: Schizophrenia is a chronic neuropsychiatric disorder with a poorly understood pathophysiology. The theories about the disorder are mainly about dysregulation in one or more systems of neurotransmitters, and the progression triggers the presence of inflammatory… read more here.
Keywords: acid supplementation; supplementation attenuates; ascorbic acid; animal model ... See more keywords
Animal Model Simulation for Training With Split‐Liver Transplants
Sign Up to like & getrecommendations! Published in 2019 at "Liver Transplantation"
DOI: 10.1002/lt.25418
Abstract: Split liver transplantation is a strategy that enhances the availability of organ transplants (1)by potentially providing liver transplants for 2 patients from a single deceased donor (2). However, because of its complexity, most programs have… read more here.
Keywords: simulation training; animal model; liver transplants; split liver ... See more keywords
Effect of lamotrigine on epilepsy‐induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole‐kindled animal model
Sign Up to like & getrecommendations! Published in 2017 at "Synapse"
DOI: 10.1002/syn.21945
Abstract: Lamotrigine (LTG) is a broad‐spectrum antiepileptic drug that is widely used in clinic. However, the effect of LTG on cognition and neurodegeneration during epilepsy treatment remains controversial. In this study, we compared the cognitive effects… read more here.
Keywords: epilepsy; animal model; effect; kindled animal ... See more keywords
Antibiotic Treatment in an Animal Model of Inflammatory Lung Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1001-5_19
Abstract: Allergic disease is on the rise and yet the underlying cause and risk factors are not fully understood. While lifesaving in many circumstances, the use of antibiotics and the subsequent disruption of the microbiome are… read more here.
Keywords: animal model; model inflammatory; disease; model ... See more keywords
Animal Model: Reflux Models in Esophageal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7734-5_13
Abstract: Many mouse models have been developed to mimic the inflammation-metaplasia-dysplasia-carcinoma sequence seen in the gastroesophageal reflux disease (GERD)-Barrett's esophagus-esophageal adenocarcinoma progression. Surgical reflux models in mice are technically challenging due to the small size and… read more here.
Keywords: model; animal model; esophageal adenocarcinoma; reflux models ... See more keywords
Monosodium Glutamate (MSG)-Induced Animal Model of Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8994-2_3
Abstract: In 1976, an animal model of type 2 diabetes (T2DM) was described by Cameron et al. using injection of monosodium glutamate (MSG) in KK mice during the neonatal period. Some years later, similar models have… read more here.
Keywords: monosodium glutamate; animal model; model type; model ... See more keywords
Animal Model of Aluminum-Induced Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1370-7_7
Abstract: Lack of a satisfactory animal model for Alzheimer's disease (AD) has limited the reach progress of the pathogenesis of the disease and of therapeutic agents aiming to important pathophysiological points. In this chapter, we analyzed… read more here.
Keywords: animal model; aluminum induced; alzheimer disease; disease ... See more keywords