Influenza antivirals and animal models.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS open bio"
DOI: 10.1002/2211-5463.13416
Abstract: Influenza A and B viruses are among the most prominent human respiratory pathogens. About 3-5 million severe cases of influenza are associated with 300,000-650,000 deaths per year globally. Antivirals effective at reducing morbidity and mortality… read more here.
Keywords: animal models; antivirals animal; influenza antivirals;
Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000305
Abstract: Regenerative medicine approaches, specifically stem cell technologies, have demonstrated significant potential to treat a diverse array of pathologies. However, such approaches have resulted in a modest clinical benefit, which may be attributed to poor cell… read more here.
Keywords: reservoir; large animal; delivery; target ... See more keywords
Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100878
Abstract: Joint repair remains a major challenge in orthopaedics. Recent progress in biomaterial design has led to the fabrication of a plethora of promising devices. Pre-clinical testing of any joint repair strategy typically requires the use… read more here.
Keywords: comparison biomaterials; systematic comparison; joint repair; large animal ... See more keywords
Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential
Sign Up to like & getrecommendations! Published in 2018 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800154
Abstract: A series of newer benzothiazolotriazine derivatives (4a–k) was designed, synthesized, and characterized as anticonvulsant agents against the two classically used MES and scPTZ animal models. The synthesized derivatives were tested in vivo in both the… read more here.
Keywords: design synthesis; benzothiazolotriazine derivatives; study; animal models ... See more keywords
Pharmacological evaluation of the effects of enzymatically liberated fish oil on eosinophilic inflammation in animal models
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2338
Abstract: The inappropriate activation of eosinophils is a well‐recognized driver of various human inflammatory diseases including asthma, chronic rhinitis, and various gastrointestinal diseases, including eosinophilic esophagitis. Steroids, both topical and systemic, remain a cornerstone of treatment… read more here.
Keywords: inflammation; fish oil; animal models; oil ... See more keywords
Advances in experimental animal models of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6163
Abstract: Hepatocellular carcinoma (HCC) is a common malignant tumor with insidious early symptoms, easy metastasis, postoperative recurrence, poor drug efficacy, and a high drug resistance rate when surgery is missed, leading to a low 5-year survival… read more here.
Keywords: hepatocellular carcinoma; animal models; experimental animal; models hepatocellular ... See more keywords
Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32220
Abstract: BACKGROUND & AIMS Liver fibrosis is the static and main (70-80%) component of portal hypertension (PH). We investigated dynamic components of PH by a 3-dimensional analysis based on correlation of hepatic collagen proportionate area (CPA)… read more here.
Keywords: different animal; dynamic components; portal hypertension; liver disease ... See more keywords
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13103
Abstract: Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality. However, cellular basis responsible for increased catabolism in myocytes… read more here.
Keywords: muscle wasting; animal models; disease; muscle ... See more keywords
The pursuit of precision mitochondrial medicine: Harnessing preclinical cellular and animal models to optimize mitochondrial disease therapeutic discovery
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12319
Abstract: Mitochondria share extensive evolutionary conservation across nearly all living species. This homology allows robust insights to be gained into pathophysiologic mechanisms and therapeutic targets for the heterogeneous class of primary mitochondrial diseases (PMDs) through the… read more here.
Keywords: medicine; disease; mitochondrial disease; gene ... See more keywords
Review of selected animal models for respiratory coronavirus infection and its application in drug research
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27718
Abstract: Numerous viral pneumonia cases have been reported in Wuhan, Hubei in December 2019. The pathogen has been identified as a novel coronavirus, which was named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The biological characteristics… read more here.
Keywords: animal models; models respiratory; coronavirus infection; respiratory coronavirus ... See more keywords
Modeling sports‐related mild traumatic brain injury in animals—A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24472
Abstract: Sports‐related head trauma has emerged as an important public health issue, as mild traumatic brain injuries (mTBIs) may result in neurodegenerative disorders such as chronic traumatic encephalopathy (CTE). Research into mTBI and CTE pathophysiology are… read more here.
Keywords: head; traumatic brain; pathology; sports related ... See more keywords